論文 - 詳細
| RRC ID | 64382 |
|---|---|
| 著者 | Huang DY, Xia XL, Huang R, Li S, Yuan DW, Liu SN. |
| タイトル | The steroid-induced microRNA let-7 regulates developmental growth by targeting cdc7 in the Drosophila fat body. |
| ジャーナル | Insect Sci |
| Abstract |
In insects, 20-hydroxyecdysone (20E) limits systemic growth by triggering developmental transitions. Previous studies have shown that 20E-induced let-7 exhibits crosstalk with the cell cycle. Here, we examined the underlying molecular mechanisms and physiological functions of 20E-induced let-7 in the fat body, an organ for energy storage and nutrient mobilization which plays a critical role in the larval growth. First, the overexpression of let-7 decreased the body size and led to the reduction of both nucleolus and cell sizes in the larval fat body. In contrast, the overexpression of let-7-Sponge increased the nucleolus and cell sizes. Moreover, we found that cdc7, encoding a conserved protein kinase that controls the endocycle, is a target of let-7. Notably, the mutation of cdc7 in the fat body resulted in growth defects. Overall, our findings revealed a novel role of let-7 in the control of endoreduplication-related growth during larval-prepupal transition in Drosophila. |
| 巻・号 | 28(6) |
| ページ | 1621-1632 |
| 公開日 | 2021-12-1 |
| DOI | 10.1111/1744-7917.12878 |
| PMID | 33089948 |
| MeSH | Animals Drosophila / genetics Drosophila / growth & development* Drosophila Proteins* / genetics Drosophila Proteins* / metabolism Ecdysterone Fat Body* / metabolism Larva MicroRNAs* / genetics Protein Serine-Threonine Kinases* / genetics Protein Serine-Threonine Kinases* / metabolism |
| IF | 2.791 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#111927 DGRC#114359 |