| RRC ID |
64432
|
| Author |
Fujishita K, Oka S, Kamei K, Tani K, Fujisawa Y, Kitamura W, Machida T, Imai T.
|
| Title |
A Disseminated Fusarium fujikuroi Species Complex Infection Prior to Allogeneic Hematopoietic Stem Cell Transplantation.
|
| Journal |
Acta Med Okayama
|
| Abstract |
A 53-year-old man was diagnosed with acute myeloid leukemia, which was refractory to chemotherapies. Systemic papules appeared afterward. The skin biopsies revealed filamentous fungal infection including fusariosis. Despite antifungal therapy, the infection did not resolve, because neutropenia persisted with the leukemia. He underwent hematopoietic stem cell transplantation (HSCT) to overcome the leukemia and restore normal hematopoiesis but died from fusariosis just before engraftment. Fusarium fujikuroi species complex was detected in blood cultures with poor antifungal susceptibility. Because restoring normal hematopoiesis is important in the treatment of fusariosis, HSCT might be considered for patients with persistent pancytopenia.
|
| Volume |
74(5)
|
| Pages |
435-441
|
| Published |
2020-10-1
|
| DOI |
10.18926/AMO/60805
|
| PMID |
33106701
|
| MeSH |
Antifungal Agents / therapeutic use*
Drug Resistance, Fungal / drug effects*
Fatal Outcome
Fusariosis / diagnosis
Fusariosis / drug therapy*
Fusarium / drug effects*
Fusarium / isolation & purification
Hematopoietic Stem Cell Transplantation / adverse effects
Humans
Leukemia, Myeloid, Acute / complications
Leukemia, Myeloid, Acute / therapy
Male
Middle Aged
Neutropenia / complications
|
| IF |
0.642
|
| Resource |
| Pathogenic eukaryotic microorganisms |
Fusarium fujikuroi species complex IFM 65844 |
