論文 - 詳細
| RRC ID | 64434 |
|---|---|
| 著者 | Furudate A, Hirose S, Abe K, Kawashima A, Hashimoto K, Yamazaki S, Kamei K, Ishiwada N, Hamada H, Sato M. |
| タイトル | Infantile Aspergillus fumigatus ventriculitis successfully treated with monitoring of plasma and cerebrospinal fluid voriconazole concentration level. |
| ジャーナル | J Infect Chemother |
| Abstract |
Aspergillosis is a rare fungal infection in newborns, and its morbidity and mortality are high. Voriconazole (VRCZ) is the first-line antifungal agent for invasive Aspergillus infection, but little data is available about its pharmacokinetics in infants. We report a case of a premature infant who developed ventriculitis due to Aspergillus fumigatus and received combination antifungal therapy including VRCZ. β-D glucan and Aspergillus antigen index were elevated in the cerebrospinal fluid (CSF). We titrated the dose of VRCZ by monitoring plasma and CSF concentrations. The CSF to plasma concentration ratio of VRCZ ranged from 0.47 to 1.36 (median 0.71). While VRCZ adequately penetrates the blood-brain barrier, its concentration is highly variable in infants. |
| 巻・号 | 26(1) |
| ページ | 132-135 |
| 公開日 | 2020-1-1 |
| DOI | 10.1016/j.jiac.2019.06.011 |
| PII | S1341-321X(19)30198-9 |
| PMID | 31350185 |
| MeSH | Antifungal Agents* / blood Antifungal Agents* / cerebrospinal fluid Antifungal Agents* / therapeutic use Aspergillus fumigatus* Cerebral Ventriculitis / drug therapy* Drug Monitoring Humans Infant, Newborn Male Neuroaspergillosis / drug therapy* Voriconazole* / blood Voriconazole* / cerebrospinal fluid Voriconazole* / therapeutic use |
| IF | 1.722 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 病原真核微生物 | Aspergillus fumigatus IFM 65289 |