論文 - 詳細
| RRC ID | 64457 |
|---|---|
| 著者 | Baltruschat L, Prisco L, Ranft P, Lauritzen JS, Fiala A, Bock DD, Tavosanis G. |
| タイトル | Circuit reorganization in the Drosophila mushroom body calyx accompanies memory consolidation. |
| ジャーナル | Cell Rep |
| Abstract |
The formation and consolidation of memories are complex phenomena involving synaptic plasticity, microcircuit reorganization, and the formation of multiple representations within distinct circuits. To gain insight into the structural aspects of memory consolidation, we focus on the calyx of the Drosophila mushroom body. In this essential center, essential for olfactory learning, second- and third-order neurons connect through large synaptic microglomeruli, which we dissect at the electron microscopy level. Focusing on microglomeruli that respond to a specific odor, we reveal that appetitive long-term memory results in increased numbers of precisely those functional microglomeruli responding to the conditioned odor. Hindering memory consolidation by non-coincident presentation of odor and reward, by blocking protein synthesis, or by including memory mutants suppress these structural changes, revealing their tight correlation with the process of memory consolidation. Thus, olfactory long-term memory is associated with input-specific structural modifications in a high-order center of the fly brain. |
| 巻・号 | 34(11) |
| ページ | 108871 |
| 公開日 | 2021-3-16 |
| DOI | 10.1016/j.celrep.2021.108871 |
| PII | S2211-1247(21)00185-6 |
| PMID | 33730583 |
| PMC | PMC8515896 |
| MeSH | Animals Axons / drug effects Axons / physiology Drosophila melanogaster / drug effects Drosophila melanogaster / physiology* Drosophila melanogaster / ultrastructure Memory Consolidation / drug effects Memory Consolidation / physiology* Memory, Long-Term / drug effects Mushroom Bodies / drug effects Mushroom Bodies / innervation* Mushroom Bodies / ultrastructure Nerve Net / drug effects Nerve Net / physiology* Nerve Net / ultrastructure Neuronal Plasticity / drug effects Odorants Oleic Acids / pharmacology Pheromones / pharmacology Synapses / drug effects Synapses / physiology Synapses / ultrastructure |
| IF | 8.109 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 15 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | |