Reference - Detail
| RRC ID | 64461 |
|---|---|
| Author | Rust K, Byrnes LE, Yu KS, Park JS, Sneddon JB, Tward AD, Nystul TG. |
| Title | A single-cell atlas and lineage analysis of the adult Drosophila ovary. |
| Journal | Nat Commun |
| Abstract |
The Drosophila ovary is a widely used model for germ cell and somatic tissue biology. Here we use single-cell RNA-sequencing (scRNA-seq) to build a comprehensive cell atlas of the adult Drosophila ovary that contains transcriptional profiles for every major cell type in the ovary, including the germline stem cells and their niche cells, follicle stem cells, and previously undescribed subpopulations of escort cells. In addition, we identify Gal4 lines with specific expression patterns and perform lineage tracing of subpopulations of escort cells and follicle cells. We discover that a distinct subpopulation of escort cells is able to convert to follicle stem cells in response to starvation or upon genetic manipulation, including knockdown of escargot, or overactivation of mTor or Toll signalling. |
| Volume | 11(1) |
| Pages | 5628 |
| Published | 2020-11-6 |
| DOI | 10.1038/s41467-020-19361-0 |
| PII | 10.1038/s41467-020-19361-0 |
| PMID | 33159074 |
| PMC | PMC7648648 |
| MeSH | Animals Cell Lineage Drosophila / cytology* Drosophila / genetics Drosophila / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism Female Ovarian Follicle / cytology Ovarian Follicle / metabolism Ovary / cytology* Ovary / metabolism Single-Cell Analysis |
| IF | 12.121 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 10 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | DGRC#112322 |