RRC ID 64465
著者 Han X, Wang M, Liu C, Trush O, Takayama R, Akiyama T, Naito T, Tomomizu T, Imamura K, Sato M.
タイトル DWnt4 and DWnt10 Regulate Morphogenesis and Arrangement of Columnar Units via Fz2/PCP Signaling in the Drosophila Brain.
ジャーナル Cell Rep
Abstract Columns are structural and functional units of the brain. However, the mechanism of column formation remains unclear. The medulla of the fly visual center shares features with the mammalian cerebral cortex, such as columnar and layered structures, and provides a good opportunity to study the mechanisms of column formation. Column formation is initiated by three core neurons in the medulla, namely, Mi1, R8, and R7. The proper orientation of neurons is required for the orientation and arrangement of multiple columns. Their orientations may be under the control of planar cell polarity (PCP) signaling, because it is known to regulate the orientation of cells in two-dimensional tissue structures. In this study, we demonstrate that the ligands DWnt4 and DWnt10 expressed specifically in the ventral medulla and dorsal medulla, respectively, globally regulate the columnar arrangement and orientation of Mi1 and R8 terminals through Fz2/PCP signaling in a three-dimensional space.
巻・号 33(4)
ページ 108305
公開日 2020-10-27
DOI 10.1016/j.celrep.2020.108305
PII S2211-1247(20)31294-8
PMID 33113378
MeSH Animals Drosophila / metabolism* Drosophila Proteins / metabolism* Frizzled Receptors / metabolism* Morphogenesis Signal Transduction Wnt Proteins / metabolism*
IF 8.109
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