RRC ID 64466
Author Yost RT, Robinson JW, Baxter CM, Scott AM, Brown LP, Aletta MS, Hakimjavadi R, Lone A, Cumming RC, Dukas R, Mozer B, Simon AF.
Title Abnormal Social Interactions in a Drosophila Mutant of an Autism Candidate Gene: Neuroligin 3.
Journal Int J Mol Sci
Abstract Social interactions are typically impaired in neuropsychiatric disorders such as autism, for which the genetic underpinnings are very complex. Social interactions can be modeled by analysis of behaviors, including social spacing, sociability, and aggression, in simpler organisms such as Drosophila melanogaster. Here, we examined the effects of mutants of the autism-related gene neuroligin 3 (nlg3) on fly social and non-social behaviors. Startled-induced negative geotaxis is affected by a loss of function nlg3 mutation. Social space and aggression are also altered in a sex- and social-experience-specific manner in nlg3 mutant flies. In light of the conserved roles that neuroligins play in social behavior, our results offer insight into the regulation of social behavior in other organisms, including humans.
Volume 21(13)
Published 2020-6-29
DOI 10.3390/ijms21134601
PII ijms21134601
PMID 32610435
PMC PMC7370170
MeSH Aggression / physiology Animals Autistic Disorder / genetics* Autistic Disorder / metabolism Behavior, Animal / physiology Cell Adhesion Molecules, Neuronal / genetics* Cell Adhesion Molecules, Neuronal / metabolism Disease Models, Animal Drosophila Proteins / metabolism Drosophila melanogaster / metabolism Female Male Membrane Proteins / genetics* Membrane Proteins / metabolism Nerve Tissue Proteins / genetics* Nerve Tissue Proteins / metabolism Social Behavior Social Interaction
IF 4.556
Drosophila DGRC#140892 DGRC#205074