| RRC ID |
64492
|
| 著者 |
Shi J, Jin Z, Yu Y, Zhang Y, Yang F, Huang H, Cai T, Xi R.
|
| タイトル |
A Progressive Somatic Cell Niche Regulates Germline Cyst Differentiation in the Drosophila Ovary.
|
| ジャーナル |
Curr Biol
|
| Abstract |
In the germarium of the Drosophila ovary, developing germline cysts are surrounded by a population of somatic escort cells that are known to function as the niche cells for germline differentiation;1 however, the underlying molecular mechanisms of this niche function remain poorly understood. Through single-cell gene expression profiling combined with genetic analyses, we here demonstrate that the escort cells can be spatially and functionally divided into two successive domains. The anterior escort cells (aECs) specifically produce ecdysone, which acts on the cystoblast to promote synchronous cell division, whereas the posterior escort cells (pECs) respond to ecdysone signaling and regulate soma-germline cell adhesion to promote the transition from 16-cell cyst-to-egg chamber formation. The patterning of the aEC and pEC domains is independent of the germline but is dependent on JAK/STAT signaling activity, which emanates from the posterior. Thus, a heterogeneous population of escort cells constitutes a stepwise niche environment to orchestrate cystoblast division and differentiation toward egg chamber formation.
|
| 巻・号 |
31(4)
|
| ページ |
840-852.e5
|
| 公開日 |
2021-2-22
|
| DOI |
10.1016/j.cub.2020.11.053
|
| PII |
S0960-9822(20)31766-8
|
| PMID |
33340458
|
| MeSH |
Animals
Cell Differentiation
Cysts*
Drosophila
Drosophila Proteins* / genetics
Drosophila melanogaster / genetics
Ecdysone* / metabolism
Female
Germ Cells
Ovary
Stem Cells
|
| IF |
9.601
|
| リソース情報 |
| ショウジョウバエ |
DGRC#113067 |
