| RRC ID |
64541
|
| Author |
Mori T, Murasawa Y, Ikai R, Hayakawa T, Nakamura H, Ogiso N, Niida S, Watanabe K.
|
| Title |
Generation of a transgenic mouse line for conditional expression of human IL-6.
|
| Journal |
Exp Anim
|
| Abstract |
IL-6 is a cytokine that is involved in various physiological and pathological conditions, and approaches using gain-of-function transgenic animals have contributed in elucidating IL-6 function. However, studies of the multiple functions of IL-6 in vivo are very time consuming because they require the generation of transgenic mice that harbor the gene encoding IL-6 under the control of specific promoters to mimic different pathologies. Here, we report the establishment of a conditional human IL-6 transgenic mouse, LGL-IL6, which conditionally expresses human IL-6 by taking advantage of the well-characterized Cre recombinase drivers.
|
| Volume |
65(4)
|
| Pages |
455-463
|
| Published |
2016-11-1
|
| DOI |
10.1538/expanim.16-0043
|
| PMID |
27349442
|
| PMC |
PMC5111849
|
| MeSH |
Animals
Gene Expression*
Humans
Interleukin-6 / genetics*
Interleukin-6 / metabolism
Mice, Transgenic / genetics*
Mice, Transgenic / metabolism
|
| IF |
1.574
|
| Resource |
| Human and Animal Cells |
7-TD-1(RCB1190) |
