論文 - 詳細
| RRC ID | 64584 |
|---|---|
| 著者 | Gallardo P, Real-Calderón P, Flor-Parra I, Salas-Pino S, Daga RR. |
| タイトル | Acute Heat Stress Leads to Reversible Aggregation of Nuclear Proteins into Nucleolar Rings in Fission Yeast. |
| ジャーナル | Cell Rep |
| Abstract |
Upon acute heat stress (HS), overall mRNA transcription, processing, and export are inhibited, leading to cell growth arrest. However, how cells turn off mRNA metabolism is not fully understood. Here, we show that acute HS results in the segregation and aggregation of multiple nuclear and nucleolar proteins into ring-like structures located at the nucleolar periphery (nucleolar rings [NuRs]). NuRs sequester essential factors required for nuclear mRNA metabolism and nuclear pore complex function, as well as cell-cycle regulators. When cells are switched back to growing temperatures, NuRs disaggregate, and their components relocate to their functional environments in an Hsf1- and Hsp104-dependent manner, and concomitantly with the reinitiation of cell growth. These findings highlight the contribution of reversible protein aggregation to the inhibition of overall RNA-related activities in the nucleus and its functional relevance in the maintenance of cellular homeostasis during acute HS. |
| 巻・号 | 33(6) |
| ページ | 108377 |
| 公開日 | 2020-11-10 |
| DOI | 10.1016/j.celrep.2020.108377 |
| PII | S2211-1247(20)31366-8 |
| PMID | 33176152 |
| MeSH | Cell Nucleolus / metabolism* Heat-Shock Response / physiology Nuclear Proteins / metabolism* Schizosaccharomyces / metabolism* |
| IF | 8.109 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 21 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 酵母 | FY15511 FY15162 FY15109 FY14636 FY23507 |