論文 - 詳細
| RRC ID | 64626 |
|---|---|
| 著者 | Yamasaki S, Shimizu K, Kometani K, Sakurai M, Kawamura M, Fujii SI. |
| タイトル | In vivo dendritic cell targeting cellular vaccine induces CD4+ Tfh cell-dependent antibody against influenza virus. |
| ジャーナル | Sci Rep |
| Abstract |
An induction of long-term cellular and humoral immunity is for the goal of vaccines, but the combination of antigens and adjuvant remain unclear. Here, we show, using a cellular vaccine carrying foreign protein antigen plus iNKT cell glycolipid antigen, designated as artificial adjuvant vector cells (aAVCs), that mature XCR1- DCs in situ elicit not only ordinal antigen-specific CD4+T cells, but also CD4+ Tfh and germinal center, resulted in inducing long-term antibody production. As a mechanism for leading the long-term antibody production by aAVC, memory CD4+ Tfh cells but not iNKTfh cells played an important role in a Bcl6 dependent manner. To develop it for influenza infection, we established influenza hemagglutinin-carrying aAVC (aAVC-HA) and found that all the mice vaccinated with aAVC-HA were protected from life-threatening influenza infection. Thus, the in vivo DC targeting therapy by aAVC would be useful for protection against viral infection. |
| 巻・号 | 6 |
| ページ | 35173 |
| 公開日 | 2016-10-14 |
| DOI | 10.1038/srep35173 |
| PII | srep35173 |
| PMID | 27739478 |
| PMC | PMC5064395 |
| MeSH | Animals Antibodies, Viral / blood* CD4-Positive T-Lymphocytes / immunology* Dendritic Cells / immunology* Disease Models, Animal Immunologic Memory Influenza Vaccines / administration & dosage Influenza Vaccines / immunology* Mice Orthomyxoviridae / immunology* Orthomyxoviridae Infections / prevention & control |
| IF | 3.998 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | NIH3T3 |