Reference - Detail
| RRC ID | 64637 |
|---|---|
| Author | Azuma T, Teramura Y, Hoshi T, Takai M. |
| Title | Enhancement of Cell Adhesion on a Phosphorylcholine-Based Surface through the Interaction with DNA Mediated by Ca2+ Ions. |
| Journal | J Phys Chem B |
| Abstract |
2-Methacryloyloxyethyl phosphorylcholine (MPC) has a PC group and is one of the most well-known bioinert polymers. In this study, we evaluated the interaction between MPC and DNA, which specifically interacts with the phospholipid head group via Ca2+ ions. A MPC monolayer and poly(MPC) brush were fabricated to observe the effect of the structure on the interaction between MPC and DNA via Ca2+ ions. The poly(MPC) brush, which shows higher MPC unit density, more efficiently interacted with DNA via Ca2+ ions. Also, serum protein could interact with the poly(MPC) brush via DNA, although the brush itself hardly interacted with serum proteins. Cell adhesion was significantly provoked on poly(MPC)/DNA compared with poly(MPC) because serum protein adsorption was induced on poly(MPC)/DNA. |
| Volume | 120(48) |
| Pages | 12272-12278 |
| Published | 2016-12-8 |
| DOI | 10.1021/acs.jpcb.6b08741 |
| PMID | 27934221 |
| MeSH | Animals Calcium / chemistry* Cell Adhesion DNA / chemistry* Ions / chemistry Male Molecular Structure Phosphorylcholine / chemistry* Salmon Spermatozoa / chemistry* Spermatozoa / cytology Surface Properties |
| IF | 2.857 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | L929 |