論文 - 詳細
| RRC ID | 64657 |
|---|---|
| 著者 | Saito Y, Kunitomi A, Seki T, Tohyama S, Kusumoto D, Takei M, Kashimura S, Hashimoto H, Yozu G, Motoda C, Shimojima M, Egashira T, Oda M, Fukuda K, Yuasa S. |
| タイトル | Epigenetic barrier against the propagation of fluctuating gene expression in embryonic stem cells. |
| ジャーナル | FEBS Lett |
| Abstract |
The expression of pluripotency genes fluctuates in a population of embryonic stem (ES) cells and the fluctuations in the expression of some pluripotency genes correlate. However, no correlation in the fluctuation of Pou5f1, Zfp42, and Nanog expression was observed in ES cells. Correlation between Pou5f1 and Zfp42 fluctuations was demonstrated in ES cells containing a knockout in the NuRD component Mbd3. ES cells containing a triple knockout in the DNA methyltransferases Dnmt1, Dnmt3a, and Dnmt3b showed correlation between the fluctuation of Pou5f1, Zfp42, and Nanog gene expression. We suggest that an epigenetic barrier is key to preventing the propagation of fluctuating pluripotency gene expression in ES cells. |
| 巻・号 | 591(18) |
| ページ | 2879-2889 |
| 公開日 | 2017-9-1 |
| DOI | 10.1002/1873-3468.12791 |
| PMID | 28805244 |
| MeSH | Animals Embryonic Stem Cells / metabolism* Epigenomics Gene Expression / genetics Mice Nanog Homeobox Protein / genetics Octamer Transcription Factor-3 / genetics Reverse Transcriptase Polymerase Chain Reaction SOXB1 Transcription Factors / genetics |
| IF | 3.057 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | Dnmt1-/-Dnmt3a-/-Dnmt3b-/- ES (clone19)(AES0146) |