RRC ID 64904
著者 Taki M, Tagami T, Fukushige K, Ozeki T.
タイトル Fabrication of nanocomposite particles using a two-solution mixing-type spray nozzle for use in an inhaled curcumin formulation.
ジャーナル Int J Pharm
Abstract A unique two-solution mixing-type spray nozzle is useful for producing nanocomposite particles (microparticles containing drug nanoparticles) in one step. The nanocomposite particles can prevent nanoparticle aggregation. Curcumin has many reported pharmacological effects. Curcumin was entrapped in mannitol microparticles using a spray dryer coupled with a two-solution mixing-type spray nozzle to prepare "curcumin nanocomposite particles" and the application of these particles for inhalation formulations was investigated. Spray drying conditions (flow rate, concentration and inlet temperature) affected the size of both the resulting curcumin nanocomposite particles and the curcumin nanoparticles in the nanocomposite particles. The aerosol performance of the curcumin nanocomposite particles changed depending on the spray drying conditions and several conditions provided better deposition compared with the curcumin original powder. The curcumin nanocomposite particles showed an improved dissolution profile of curcumin compared with the original powder. Furthermore, the curcumin nanocomposite particles showed a higher cytotoxic effect compared with the curcumin original powder towards three cancer cell lines. Curcumin nanocomposite particles containing curcumin nanoparticles show promise as an inhalation formulation for treating lung-related diseases including cancer.
巻・号 511(1)
ページ 104-110
公開日 2016-9-10
DOI 10.1016/j.ijpharm.2016.06.134
PII S0378-5173(16)30624-X
PMID 27374204
MeSH Administration, Inhalation Animals Cell Line, Tumor Cell Survival / drug effects Cell Survival / physiology Chemistry, Pharmaceutical / methods* Curcumin / administration & dosage Curcumin / chemical synthesis* Dose-Response Relationship, Drug Drug Compounding Humans Melanoma, Experimental Mice Nanocomposites / administration & dosage Nanocomposites / chemistry* Particle Size
IF 4.845
リソース情報
ヒト・動物細胞 B16/BL6(RCB2638) RAW 264(RCB0535)