| RRC ID |
64919
|
| 著者 |
Nguyen HX, Do TN, Le TH, Nguyen MT, Nguyen NT, Esumi H, Awale S.
|
| タイトル |
Chemical Constituents of Mangifera indica and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line.
|
| ジャーナル |
J Nat Prod
|
| Abstract |
Human pancreatic cancer cell lines such as PANC-1 have an altered metabolism, enabiling them to tolerate and survive under extreme conditions of nutrient starvation. The search for candidates that inhibit their viability during nutrition starvation represents a novel antiausterity strategy in anticancer drug discovery. A methanol extract of the bark of Mangifera indica was found to inhibit the survival of PANC-1 human pancreatic cancer cells preferentially under nutrient-deprived conditions with a PC50 value of 15.5 μg/mL, without apparent toxicity, in normal nutrient-rich conditions. Chemical investigation on this bioactive extract led to the isolation of 19 compounds (1-19), including two new cycloartane-type triterpenes, mangiferolate A (1) and mangiferolate B (2). The structures of 1 and 2 were determined by NMR spectroscopic analysis. Among the isolated compounds, mangiferolate B (2) and isoambolic acid (12) exhibited potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under the nutrition-deprived condition with PC50 values of 11.0 and 4.8 μM, respectively.
|
| 巻・号 |
79(8)
|
| ページ |
2053-9
|
| 公開日 |
2016-8-26
|
| DOI |
10.1021/acs.jnatprod.6b00381
|
| PMID |
27466882
|
| MeSH |
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology*
Drug Screening Assays, Antitumor
Humans
Mangifera / chemistry*
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Pancreatic Neoplasms / drug therapy*
Plant Bark / chemistry
Triterpenes / chemistry
Triterpenes / isolation & purification*
Triterpenes / pharmacology*
Vietnam
|
| IF |
3.782
|
| リソース情報 |
| ヒト・動物細胞 |
PANC-1(RCB2095) |
