論文 - 詳細
| RRC ID | 64919 |
|---|---|
| 著者 | Nguyen HX, Do TN, Le TH, Nguyen MT, Nguyen NT, Esumi H, Awale S. |
| タイトル | Chemical Constituents of Mangifera indica and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line. |
| ジャーナル | J Nat Prod |
| Abstract |
Human pancreatic cancer cell lines such as PANC-1 have an altered metabolism, enabiling them to tolerate and survive under extreme conditions of nutrient starvation. The search for candidates that inhibit their viability during nutrition starvation represents a novel antiausterity strategy in anticancer drug discovery. A methanol extract of the bark of Mangifera indica was found to inhibit the survival of PANC-1 human pancreatic cancer cells preferentially under nutrient-deprived conditions with a PC50 value of 15.5 μg/mL, without apparent toxicity, in normal nutrient-rich conditions. Chemical investigation on this bioactive extract led to the isolation of 19 compounds (1-19), including two new cycloartane-type triterpenes, mangiferolate A (1) and mangiferolate B (2). The structures of 1 and 2 were determined by NMR spectroscopic analysis. Among the isolated compounds, mangiferolate B (2) and isoambolic acid (12) exhibited potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under the nutrition-deprived condition with PC50 values of 11.0 and 4.8 μM, respectively. |
| 巻・号 | 79(8) |
| ページ | 2053-9 |
| 公開日 | 2016-8-26 |
| DOI | 10.1021/acs.jnatprod.6b00381 |
| PMID | 27466882 |
| MeSH | Antineoplastic Agents, Phytogenic / chemistry Antineoplastic Agents, Phytogenic / isolation & purification* Antineoplastic Agents, Phytogenic / pharmacology* Drug Screening Assays, Antitumor Humans Mangifera / chemistry* Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pancreatic Neoplasms / drug therapy* Plant Bark / chemistry Triterpenes / chemistry Triterpenes / isolation & purification* Triterpenes / pharmacology* Vietnam |
| IF | 3.782 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | PANC-1(RCB2095) |