| RRC ID |
64990
|
| 著者 |
Hirai C, Badawy SMM, Zhang L, Okada T, Kajimoto T, Nakamura S.
|
| タイトル |
Phospholipase D is Dispensable for Epidermal Growth Factor-Induced Chemotaxis.
|
| ジャーナル |
Kobe J Med Sci
|
| Abstract |
α-Synuclein (α-Syn) is implicated in several neurodegenerative disorders, including Parkinson's disease, known collectively as the synucleinopathies. α-Syn is known to be secreted from the cells and may contribute to the progression of the disease. Although extracellular α-Syn is shown to impair platelet-derived growth factor-induced chemotaxis, molecular mechanism of α-Syn-induced motility failure remains elusive. Here we have aimed at phospholipase D (PLD) as a potential target for α-Syn and examined the involvement of this enzyme in α-Syn action. Indeed, extracellular α-Syn caused inhibition of agonist-induced PLD activation. However, inhibition of hydrolytic activity of PLD by 1-butanol treatment showed little or no effect on agonist-induced chemotaxis. These results suggest that some signaling pathways other than PLD may be involved in α-Syn-induced inhibition of chemotaxis.
|
| 巻・号 |
62(6)
|
| ページ |
E162-E167
|
| 公開日 |
2017-5-9
|
| PMID |
28490713
|
| PMC |
PMC5436530
|
| MeSH |
Animals
COS Cells
Chemotaxis*
Chlorocebus aethiops
Phospholipase D / metabolism*
alpha-Synuclein / physiology*
|
| リソース情報 |
| ヒト・動物細胞 |
COS-7(RCB0539) |
