論文 - 詳細
| RRC ID | 64990 |
|---|---|
| 著者 | Hirai C, Badawy SMM, Zhang L, Okada T, Kajimoto T, Nakamura S. |
| タイトル | Phospholipase D is Dispensable for Epidermal Growth Factor-Induced Chemotaxis. |
| ジャーナル | Kobe J Med Sci |
| Abstract |
α-Synuclein (α-Syn) is implicated in several neurodegenerative disorders, including Parkinson's disease, known collectively as the synucleinopathies. α-Syn is known to be secreted from the cells and may contribute to the progression of the disease. Although extracellular α-Syn is shown to impair platelet-derived growth factor-induced chemotaxis, molecular mechanism of α-Syn-induced motility failure remains elusive. Here we have aimed at phospholipase D (PLD) as a potential target for α-Syn and examined the involvement of this enzyme in α-Syn action. Indeed, extracellular α-Syn caused inhibition of agonist-induced PLD activation. However, inhibition of hydrolytic activity of PLD by 1-butanol treatment showed little or no effect on agonist-induced chemotaxis. These results suggest that some signaling pathways other than PLD may be involved in α-Syn-induced inhibition of chemotaxis. |
| 巻・号 | 62(6) |
| ページ | E162-E167 |
| 公開日 | 2017-5-9 |
| PMID | 28490713 |
| PMC | PMC5436530 |
| MeSH | Animals COS Cells Chemotaxis* Chlorocebus aethiops Phospholipase D / metabolism* alpha-Synuclein / physiology* |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | COS-7(RCB0539) |