論文 - 詳細
| RRC ID | 65001 |
|---|---|
| 著者 | Kariya Y, Oyama M, Suzuki T, Kariya Y. |
| タイトル | αvβ3 Integrin induces partial EMT independent of TGF-β signaling. |
| ジャーナル | Commun Biol |
| Abstract |
Epithelial-mesenchymal transition (EMT) plays a pivotal role for tumor progression. Recent studies have revealed the existence of distinct intermediate states in EMT (partial EMT); however, the mechanisms underlying partial EMT are not fully understood. Here, we demonstrate that αvβ3 integrin induces partial EMT, which is characterized by acquiring mesenchymal phenotypes while retaining epithelial markers. We found αvβ3 integrin to be associated with poor survival in patients with lung adenocarcinoma. Moreover, αvβ3 integrin-induced partial EMT promoted migration, invasion, tumorigenesis, stemness, and metastasis of lung cancer cells in a TGF-β-independent fashion. Additionally, TGF-β1 promoted EMT progression synergistically with αvβ3 integrin, while a TGF-β signaling inhibitor showed no effect on αvβ3 integrin-induced partial EMT. Meanwhile, the microRNA-200 family abolished the αvβ3 integrin-induced partial EMT by suppressing αvβ3 integrin cell surface expression. These findings indicate that αvβ3 integrin is a key inducer of partial EMT, and highlight a new mechanism for cancer progression. |
| 巻・号 | 4(1) |
| ページ | 490 |
| 公開日 | 2021-4-21 |
| DOI | 10.1038/s42003-021-02003-6 |
| PII | 10.1038/s42003-021-02003-6 |
| PMID | 33883697 |
| PMC | PMC8060333 |
| MeSH | Animals Epithelial-Mesenchymal Transition / genetics* Female Integrin alphaVbeta3 / genetics* Integrin alphaVbeta3 / metabolism Mice Mice, Nude Transforming Growth Factor beta1 / genetics* Transforming Growth Factor beta1 / metabolism |
| IF | 4.165 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | 293T(RCB2202) A549(RCB0098) |