Reference - Detail
| RRC ID | 6503 |
|---|---|
| Author | Miyata S, Uchinokura S, Fukushima T, Hamasuna R, Itoh H, Akiyama Y, Nakano S, Wakisaka S, Kataoka H. |
| Title | Diverse roles of hepatocyte growth factor activator inhibitor type 1 (HAI-1) in the growth of glioblastoma cells in vivo. |
| Journal | Cancer Lett |
| Abstract |
Hepatocyte growth factor activator inhibitor type-1 (HAI-1) is an integral-membrane proteinase inhibitor. In this study, we examined the effects of HAI-1 on human glioblastoma cells. Two glioblastoma cell lines (YKG-1, U251) were stably transfected with expression plasmid harboring mature membrane-form or truncated secreted-form HAI-1. Culture characteristics were not altered by the expression of HAI-1, whereas in vitro invasiveness of U251 was suppressed. On the other hand, the expression of membrane-form HAI-1 resulted in significantly enhanced tumorigenicity of both cell lines in vivo. In contrast, secreted-form HAI-1 did not promote the tumorigenicity. These results suggest that HAI-1 may play complex roles in progression of glioblastoma cells, and membrane-form HAI-1 may mediate an undefined important signaling in the cells. |
| Volume | 227(1) |
| Pages | 83-93 |
| Published | 2005-9-8 |
| DOI | 10.1016/j.canlet.2005.01.010 |
| PII | S0304-3835(05)00041-8 |
| PMID | 16051034 |
| MeSH | Animals Cell Line, Tumor Glioblastoma / pathology* Humans Male Membrane Glycoproteins / genetics Membrane Glycoproteins / physiology* Mice Mice, Inbred BALB C Proteinase Inhibitory Proteins, Secretory |
| IF | 7.36 |
| Times Cited | 9 |
| WOS Category | ONCOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | KG-1-C(RCB0270) |