| RRC ID |
65047
|
| Author |
Nguyen HX, Nguyen MTT, Nguyen NT, Awale S.
|
| Title |
Chemical Constituents of Propolis from Vietnamese Trigona minor and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line.
|
| Journal |
J Nat Prod
|
| Abstract |
The ethanol extract of propolis from the Vietnamese stingless bee Trigona minor possessed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells in nutrient-deprived medium, with a PC50 value of 14.0 μg/mL. Chemical investigation of this extract led to the isolation of 15 cycloartane-type triterpenoids, including five new compounds (1-5), and a lanostane-type triterpenoid. The structures of the new compounds were elucidated on the basis of NMR spectroscopic analysis. Among the isolated compounds, 23-hydroxyisomangiferolic acid B (5) and 27-hydroxyisomangiferolic acid (13) exhibited the most potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived conditions, with PC50 values of 4.3 and 3.7 μM, respectively.
|
| Volume |
80(8)
|
| Pages |
2345-2352
|
| Published |
2017-8-25
|
| DOI |
10.1021/acs.jnatprod.7b00375
|
| PMID |
28783356
|
| MeSH |
Animals
Antineoplastic Agents, Phytogenic / chemistry
Cell Line, Tumor
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Pancreatic Neoplasms / drug therapy*
Propolis / chemistry*
Triterpenes / chemistry
Triterpenes / isolation & purification*
Triterpenes / pharmacology*
Vietnam
|
| IF |
3.782
|
| Resource |
| Human and Animal Cells |
PANC-1(RCB2095) |
