論文 - 詳細
| RRC ID | 65058 |
|---|---|
| 著者 | Dang PH, Nguyen HX, Duong TTT, Tran TKT, Nguyen PT, Vu TKT, Vuong HC, Phan NHT, Nguyen MTT, Nguyen NT, Awale S. |
| タイトル | α-Glucosidase Inhibitory and Cytotoxic Taxane Diterpenoids from the Stem Bark of Taxus wallichiana. |
| ジャーナル | J Nat Prod |
| Abstract |
From a CH2Cl2 extract of the bark of Taxus wallichiana, six new taxoids, wallitaxanes A-F (1-6), were isolated, together with 29 known compounds. The structures of the new compounds were elucidated on the basis of spectroscopic data interpretation. Wallitaxane D (4) was identified as an opened oxetane-type taxoid having the first naturally occurring C(H)-20 acetal group, while wallitaxanes E (5) and F (6) are representative of the rare abeo-taxoid class. The isolated compounds were evaluated for their α-glucosidase inhibitory activity and for cytotoxicity against the HeLa human cervical cancer cell line. In the present work, taxanes were found to exhibit α-glucosidase inhibitory activity for the first time, and wallitaxane A (1) showed the most potent effect, with an IC50 value of 3.6 μM. In turn, 7-epi-taxol (16) and 7-epi-10-deacetyltaxol (17) showed IC50 values of 0.05 and 0.085 nM, respectively, against HeLa cells. |
| 巻・号 | 80(4) |
| ページ | 1087-1095 |
| 公開日 | 2017-4-28 |
| DOI | 10.1021/acs.jnatprod.7b00006 |
| PMID | 28240909 |
| MeSH | Antineoplastic Agents, Phytogenic / chemistry Antineoplastic Agents, Phytogenic / isolation & purification* Antineoplastic Agents, Phytogenic / pharmacology Bridged-Ring Compounds / chemistry* Diterpenes / chemistry Diterpenes / isolation & purification* Diterpenes / pharmacology* Glycoside Hydrolase Inhibitors / chemistry Glycoside Hydrolase Inhibitors / isolation & purification* Glycoside Hydrolase Inhibitors / pharmacology* Humans Molecular Structure Paclitaxel / pharmacology Plant Bark / chemistry* Taxoids / chemistry Taxoids / isolation & purification* Taxoids / pharmacology* Taxus / chemistry* alpha-Glucosidases |
| IF | 3.782 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | heLa(RCB0007) |