RRC ID 65058
著者 Dang PH, Nguyen HX, Duong TTT, Tran TKT, Nguyen PT, Vu TKT, Vuong HC, Phan NHT, Nguyen MTT, Nguyen NT, Awale S.
タイトル α-Glucosidase Inhibitory and Cytotoxic Taxane Diterpenoids from the Stem Bark of Taxus wallichiana.
ジャーナル J Nat Prod
Abstract From a CH2Cl2 extract of the bark of Taxus wallichiana, six new taxoids, wallitaxanes A-F (1-6), were isolated, together with 29 known compounds. The structures of the new compounds were elucidated on the basis of spectroscopic data interpretation. Wallitaxane D (4) was identified as an opened oxetane-type taxoid having the first naturally occurring C(H)-20 acetal group, while wallitaxanes E (5) and F (6) are representative of the rare abeo-taxoid class. The isolated compounds were evaluated for their α-glucosidase inhibitory activity and for cytotoxicity against the HeLa human cervical cancer cell line. In the present work, taxanes were found to exhibit α-glucosidase inhibitory activity for the first time, and wallitaxane A (1) showed the most potent effect, with an IC50 value of 3.6 μM. In turn, 7-epi-taxol (16) and 7-epi-10-deacetyltaxol (17) showed IC50 values of 0.05 and 0.085 nM, respectively, against HeLa cells.
巻・号 80(4)
ページ 1087-1095
公開日 2017-4-28
DOI 10.1021/acs.jnatprod.7b00006
PMID 28240909
MeSH Antineoplastic Agents, Phytogenic / chemistry Antineoplastic Agents, Phytogenic / isolation & purification* Antineoplastic Agents, Phytogenic / pharmacology Bridged-Ring Compounds / chemistry* Diterpenes / chemistry Diterpenes / isolation & purification* Diterpenes / pharmacology* Glycoside Hydrolase Inhibitors / chemistry Glycoside Hydrolase Inhibitors / isolation & purification* Glycoside Hydrolase Inhibitors / pharmacology* Humans Molecular Structure Paclitaxel / pharmacology Plant Bark / chemistry* Taxoids / chemistry Taxoids / isolation & purification* Taxoids / pharmacology* Taxus / chemistry* alpha-Glucosidases
IF 3.782
リソース情報
ヒト・動物細胞 heLa(RCB0007)