論文 - 詳細
| RRC ID | 65202 |
|---|---|
| 著者 | Perez MA, Magtanong L, Dixon SJ, Watts JL. |
| タイトル | Dietary Lipids Induce Ferroptosis in Caenorhabditiselegans and Human Cancer Cells. |
| ジャーナル | Dev Cell |
| Abstract |
Dietary lipids impact development, homeostasis, and disease, but links between specific dietary fats and cell fates are poorly understood. Ferroptosis is an iron-dependent form of nonapoptotic cell death associated with oxidized polyunsaturated phospholipids. Here, we show that dietary ingestion of the polyunsaturated fatty acid (PUFA) dihomogamma-linolenic acid (DGLA; 20:3n-6) can trigger germ-cell ferroptosis and sterility in the nematode Caenorhabditis elegans. Exogenous DGLA is also sufficient to induce ferroptosis in human cells, pinpointing this omega-6 PUFA as a conserved metabolic instigator of this lethal process. In both C. elegans and human cancer cells, ether-lipid synthesis protects against ferroptosis. These results establish C. elegans as a powerful animal model to study the induction and modulation of ferroptosis by dietary fats and indicate that endogenous ether lipids act to prevent this nonapoptotic cell fate. |
| 巻・号 | 54(4) |
| ページ | 447-454.e4 |
| 公開日 | 2020-8-24 |
| DOI | 10.1016/j.devcel.2020.06.019 |
| PII | S1534-5807(20)30498-6 |
| PMID | 32652074 |
| PMC | PMC7483868 |
| MeSH | 8,11,14-Eicosatrienoic Acid / metabolism 8,11,14-Eicosatrienoic Acid / pharmacology* Animals Caenorhabditis elegans / drug effects Caenorhabditis elegans / genetics Cell Death / drug effects Cell Differentiation / drug effects Cell Line, Tumor Dietary Fats / metabolism* Dietary Fats / pharmacology Ferroptosis / drug effects* Germ Cells / drug effects Homeostasis / drug effects Humans Iron / metabolism Lipids / genetics Lipids / pharmacology* Neoplasms / metabolism Neoplasms / pathology Phospholipids / pharmacology |
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オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 76 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2100 |