論文 - 詳細
| RRC ID | 65206 |
|---|---|
| 著者 | Abay-Nørgaard S, Attianese B, Boreggio L, Salcini AE. |
| タイトル | Regulators of H3K4 methylation mutated in neurodevelopmental disorders control axon guidance in Caenorhabditis elegans. |
| ジャーナル | Development |
| Abstract |
Post-translational histone modifications regulate chromatin compaction and gene expression to control many aspects of development. Mutations in genes encoding regulators of H3K4 methylation are causally associated with neurodevelopmental disorders characterized by intellectual disability and deficits in motor functions. However, it remains unclear how H3K4 methylation influences nervous system development and contributes to the aetiology of disease. Here, we show that the catalytic activity of set-2, the Caenorhabditis elegans homologue of the H3K4 methyltransferase KMT2F/G (SETD1A/B) genes, controls embryonic transcription of neuronal genes and is required for establishing proper axon guidance, and for neuronal functions related to locomotion and learning. Moreover, we uncover a striking correlation between components of the H3K4 regulatory machinery mutated in neurodevelopmental disorders and the process of axon guidance in C. elegans Thus, our study supports an epigenetic-based model for the aetiology of neurodevelopmental disorders, based on an aberrant axon guidance process originating from deregulated H3K4 methylation. |
| 巻・号 | 147(15) |
| 公開日 | 2020-8-7 |
| DOI | 10.1242/dev.190637 |
| PII | dev.190637 |
| PMID | 32675280 |
| PMC | PMC7420840 |
| MeSH | Animals Axon Guidance* Caenorhabditis elegans / embryology* Caenorhabditis elegans / genetics Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Histones / genetics Histones / metabolism* Methylation Neurodevelopmental Disorders / genetics Neurodevelopmental Disorders / metabolism* Neurogenesis* Nuclear Proteins / genetics Nuclear Proteins / metabolism* |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1630 tm5092 tm3141 tm3713 tm1905 tm3463 |