RRC ID 65217
Author Yan J, Zhao N, Yang Z, Li Y, Bai H, Zou W, Zhang K, Huang X.
Title A trade-off switch of two immunological memories in Caenorhabditis elegans reinfected by bacterial pathogens.
Journal J Biol Chem
Abstract Recent studies have suggested that innate immune responses exhibit characteristics associated with memory linked to modulations in both vertebrates and invertebrates. However, the diverse evolutionary paths taken, particularly within the invertebrate taxa, should lead to similarly diverse innate immunity memory processes. Our understanding of innate immune memory in invertebrates primarily comes from studies of the fruit fly Drosophila melanogaster, the generality of which is unclear. Caenorhabditis elegans typically inhabits soil harboring a variety of fatal microbial pathogens; for this invertebrate, the innate immune system and aversive behavior are the major defensive strategies against microbial infection. However, their characteristics of immunological memory remains infantile. Here we discovered an immunological memory that promoted avoidance and suppressed innate immunity during reinfection with bacteria, which we revealed to be specific to the previously exposed pathogens. During this trade-off switch of avoidance and innate immunity, the chemosensory neurons AWB and ADF modulated production of serotonin and dopamine, which in turn decreased expression of the innate immunity-associated genes and led to enhanced avoidance via the downstream insulin-like pathway. Therefore, our current study profiles the immune memories during C. elegans reinfected by pathogenic bacteria and further reveals that the chemosensory neurons, the neurotransmitter(s), and their associated molecular signaling pathways are responsible for a trade-off switch between the two immunological memories.
Volume 295(50)
Pages 17323-17336
Published 2020-12-11
DOI 10.1074/jbc.RA120.013923
PII S0021-9258(17)50619-5
PMID 33051209
PMC PMC7863904
MeSH Animals Bacteria / immunology* Bacterial Infections / immunology* Caenorhabditis elegans / immunology* Caenorhabditis elegans / microbiology Dopamine / immunology* Immunity, Innate* Immunologic Memory* Serotonin / immunology*
Resource
C.elegans tm1907 tm2261