論文 - 詳細
| RRC ID | 65328 |
|---|---|
| 著者 | Brena D, Bertran J, Porta-de-la-Riva M, Guillén Y, Cornes E, Kukhtar D, Campos-Vicens L, Fernández L, Pecharroman I, García-López A, Islam ABMMK, Marruecos L, Bigas A, Cerón J, Espinosa L. |
| タイトル | Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development. |
| ジャーナル | Sci Rep |
| Abstract |
Mammalian IκB proteins (IκBs) exert their main function as negative regulators of NF-κB, a central signaling pathway controlling immunity and inflammation. An alternative chromatin role for IκBs has been shown to affect stemness and cell differentiation. However, the involvement of NF-κB in this function has not been excluded. NFKI-1 and IKB-1 are IκB homologs in Caenorhabditis elegans, which lacks NF-κB nuclear effectors. We found that nfki-1 and ikb-1 mutants display developmental defects that phenocopy mutations in Polycomb and UTX-1 histone demethylase, suggesting a role for C. elegans IκBs in chromatin regulation. Further supporting this possibility (1) we detected NFKI-1 in the nucleus of cells; (2) NFKI-1 and IKB-1 bind to histones and Polycomb proteins, (3) and associate with chromatin in vivo, and (4) mutations in nfki-1 and ikb-1 alter chromatin marks. Based on these results, we propose that ancestral IκB inhibitors modulate Polycomb activity at specific gene subsets with an impact on development. |
| 巻・号 | 10(1) |
| ページ | 16153 |
| 公開日 | 2020-9-30 |
| DOI | 10.1038/s41598-020-73146-5 |
| PII | 10.1038/s41598-020-73146-5 |
| PMID | 32999373 |
| PMC | PMC7527347 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cell Differentiation / physiology Chromatin / metabolism* I-kappa B Proteins / genetics I-kappa B Proteins / metabolism* Polycomb-Group Proteins / genetics Polycomb-Group Proteins / metabolism* |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 25 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3585 tm5166 |