| RRC ID |
65350
|
| 著者 |
Stec N, Doerfel K, Hills-Muckey K, Ettorre VM, Ercan S, Keil W, Hammell CM.
|
| タイトル |
An Epigenetic Priming Mechanism Mediated by Nutrient Sensing Regulates Transcriptional Output during C. elegans Development.
|
| ジャーナル |
Curr Biol
|
| Abstract |
Although precise tuning of gene expression levels is critical for most developmental pathways, the mechanisms by which the transcriptional output of dosage-sensitive molecules is established or modulated by the environment remain poorly understood. Here, we provide a mechanistic framework for how the conserved transcription factor BLMP-1/Blimp1 operates as a pioneer factor to decompact chromatin near its target loci during embryogenesis (hours prior to major transcriptional activation) and, by doing so, regulates both the duration and amplitude of subsequent target gene transcription during post-embryonic development. This priming mechanism is genetically separable from the mechanisms that establish the timing of transcriptional induction and functions to canalize aspects of cell-fate specification, animal size regulation, and molting. A key feature of the BLMP-1-dependent transcriptional priming mechanism is that chromatin decompaction is initially established during embryogenesis and maintained throughout larval development by nutrient sensing. This anticipatory mechanism integrates transcriptional output with environmental conditions and is essential for resuming normal temporal patterning after animals exit nutrient-mediated developmental arrests.
|
| 巻・号 |
31(4)
|
| ページ |
809-826.e6
|
| 公開日 |
2021-2-22
|
| DOI |
10.1016/j.cub.2020.11.060
|
| PII |
S0960-9822(20)31773-5
|
| PMID |
33357451
|
| PMC |
PMC7904604
|
| MeSH |
Animals
Caenorhabditis elegans* / genetics
Caenorhabditis elegans* / metabolism
Caenorhabditis elegans Proteins* / genetics
Caenorhabditis elegans Proteins* / metabolism
Chromatin
Epigenesis, Genetic*
Gene Expression Regulation, Developmental*
Nutrients
Transcription Factors / metabolism
|
| リソース情報 |
| 線虫 |
tm548 |
