論文 - 詳細
| RRC ID | 65351 |
|---|---|
| 著者 | Qi W, Gromoff EDV, Xu F, Zhao Q, Yang W, Pfeifer D, Maier W, Long L, Baumeister R. |
| タイトル | The secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans. |
| ジャーナル | Nat Commun |
| Abstract |
Multicellular organisms coordinate tissue specific responses to environmental information via both cell-autonomous and non-autonomous mechanisms. In addition to secreted ligands, recent reports implicated release of small RNAs in regulating gene expression across tissue boundaries. Here, we show that the conserved poly-U specific endoribonuclease ENDU-2 in C. elegans is secreted from the soma and taken-up by the germline to ensure germline immortality at elevated temperature. ENDU-2 binds to mature mRNAs and negatively regulates mRNA abundance both in the soma and the germline. While ENDU-2 promotes RNA decay in the soma directly via its endoribonuclease activity, ENDU-2 prevents misexpression of soma-specific genes in the germline and preserves germline immortality independent of its RNA-cleavage activity. In summary, our results suggest that the secreted RNase ENDU-2 regulates gene expression across tissue boundaries in response to temperature alterations and contributes to maintenance of stem cell immortality, probably via retaining a stem cell specific program of gene expression. |
| 巻・号 | 12(1) |
| ページ | 1262 |
| 公開日 | 2021-2-24 |
| DOI | 10.1038/s41467-021-21516-6 |
| PII | 10.1038/s41467-021-21516-6 |
| PMID | 33627668 |
| PMC | PMC7904951 |
| MeSH | Animals Caenorhabditis elegans / enzymology* Caenorhabditis elegans / genetics* Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Endoribonucleases / genetics Endoribonucleases / metabolism* Germ-Line Mutation / genetics RNA Stability / genetics RNA Stability / physiology RNA, Messenger / metabolism Stem Cells / cytology Stem Cells / metabolism Temperature |
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オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 17 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm4977 tm1200 tm1977 |