| RRC ID |
6545
|
| Author |
Sawai H, Domae N.
|
| Title |
Release of cytochrome c from mitochondria precedes Bax translocation/activation in Triton X-100-induced apoptosis.
|
| Journal |
Leuk Res
|
| Abstract |
The precise mechanisms by which sublytic concentrations of detergents induce apoptosis remain unclear. Recent studies reported the ability of nonionic detergents such as Triton X-100 to induce conformational change of Bax to the active form in vitro. Here we investigated whether activation of Bax might play a role in Triton X-100-induced apoptosis in cells. Although Bax translocation/activation was inhibited by caspase inhibitors, cytochrome c release from mitochondria was not affected in Triton X-100-induced apoptosis in U-937 cells. These results demonstrate that translocation/activation of Bax occurs downstream of cytochrome c release and caspase activation in Triton X-100-induced apoptosis.
|
| Volume |
32(3)
|
| Pages |
445-53
|
| Published |
2008-3-1
|
| DOI |
10.1016/j.leukres.2007.06.018
|
| PII |
S0145-2126(07)00263-9
|
| PMID |
17689609
|
| MeSH |
Apoptosis / drug effects
Caspases / biosynthesis
Cytochromes c / metabolism*
Humans
Mitochondria / metabolism*
Octoxynol
U937 Cells
bcl-2-Associated X Protein / metabolism*
|
| IF |
2.214
|
| Times Cited |
10
|
|
WOS Category
|
HEMATOLOGY
ONCOLOGY
|
| Resource |
| Human and Animal Cells |
U-937 |
