RRC ID |
6545
|
Author |
Sawai H, Domae N.
|
Title |
Release of cytochrome c from mitochondria precedes Bax translocation/activation in Triton X-100-induced apoptosis.
|
Journal |
Leuk Res
|
Abstract |
The precise mechanisms by which sublytic concentrations of detergents induce apoptosis remain unclear. Recent studies reported the ability of nonionic detergents such as Triton X-100 to induce conformational change of Bax to the active form in vitro. Here we investigated whether activation of Bax might play a role in Triton X-100-induced apoptosis in cells. Although Bax translocation/activation was inhibited by caspase inhibitors, cytochrome c release from mitochondria was not affected in Triton X-100-induced apoptosis in U-937 cells. These results demonstrate that translocation/activation of Bax occurs downstream of cytochrome c release and caspase activation in Triton X-100-induced apoptosis.
|
Volume |
32(3)
|
Pages |
445-53
|
Published |
2008-3-1
|
DOI |
10.1016/j.leukres.2007.06.018
|
PII |
S0145-2126(07)00263-9
|
PMID |
17689609
|
MeSH |
Apoptosis / drug effects
Caspases / biosynthesis
Cytochromes c / metabolism*
Humans
Mitochondria / metabolism*
Octoxynol
U937 Cells
bcl-2-Associated X Protein / metabolism*
|
IF |
2.214
|
Times Cited |
10
|
WOS Category
|
HEMATOLOGY
ONCOLOGY
|
Resource |
Human and Animal Cells |
|