Reference - Detail
|Author||Hayano A, Komohara Y, Takashima Y, Takeya H, Homma J, Fukai J, Iwadate Y, Kajiwara K, Ishizawa S, Hondoh H, Yamanaka R.|
|Title||Programmed Cell Death Ligand 1 Expression in Primary Central Nervous System Lymphomas: A Clinicopathological Study.|
BACKGROUND/AIM:Programmed cell death ligand 1 (PD-L1)/programmed cell death 1 (PD-1) have been shown to predict response to PD-L1/PD-1-targeted therapy. We analyzed PD-L1 expression in primary central nervous system lymphomas (PCNSLs).
MATERIALS AND METHODS:PD-L1 protein and mRNA expression were evaluated in 64 PCNSL tissue samples. IFN-γ, IL-10, CD4, and CD8 mRNA expression was also evaluated.
RESULTS:PD-L1 protein was detected in tumor cells in 2 (4.1%) cases and in tumor microenvironments in 25 (52%) cases. PD-L1 mRNA positively correlated with IFN-γ (p=0.0024) and CD4 (p=0.0005) mRNA expression. IFN-γ mRNA positively correlated with CD8 mRNA expression (p=0.0001). Furthermore, tumor cell PD-L1 expression correlated positively with overall survival (p=0.0177), whereas microenvironmental PD-L1 expression exhibited an insignificant negative trend with overall survival (p=0.188).
CONCLUSION:PD-L1 was expressed on both tumor and/or tumor-infiltrating immune cells in PCNSL. The biological roles of this marker warrant further investigation.
|MeSH||Adult Aged Aged, 80 and over B7-H1 Antigen* / analysis B7-H1 Antigen* / genetics Biomarkers, Tumor* / analysis Biomarkers, Tumor* / genetics CD4 Antigens / genetics CD4-Positive T-Lymphocytes / chemistry CD4-Positive T-Lymphocytes / pathology CD8 Antigens / genetics CD8-Positive T-Lymphocytes / chemistry CD8-Positive T-Lymphocytes / pathology Central Nervous System Neoplasms / chemistry* Central Nervous System Neoplasms / genetics* Central Nervous System Neoplasms / mortality Central Nervous System Neoplasms / pathology Disease-Free Survival Female Humans Interferon-gamma / genetics Interleukin-10 / genetics Kaplan-Meier Estimate Lymphocytes, Tumor-Infiltrating / chemistry Lymphocytes, Tumor-Infiltrating / pathology Lymphoma / chemistry* Lymphoma / genetics* Lymphoma / mortality Lymphoma / pathology Male Middle Aged Proportional Hazards Models RNA, Messenger / genetics Retrospective Studies Tumor Microenvironment|
|Human and Animal Cells||Raji|