RRC ID 65466
Author Hayano A, Komohara Y, Takashima Y, Takeya H, Homma J, Fukai J, Iwadate Y, Kajiwara K, Ishizawa S, Hondoh H, Yamanaka R.
Title Programmed Cell Death Ligand 1 Expression in Primary Central Nervous System Lymphomas: A Clinicopathological Study.
Journal Anticancer Res
Abstract BACKGROUND/AIM:Programmed cell death ligand 1 (PD-L1)/programmed cell death 1 (PD-1) have been shown to predict response to PD-L1/PD-1-targeted therapy. We analyzed PD-L1 expression in primary central nervous system lymphomas (PCNSLs).
MATERIALS AND METHODS:PD-L1 protein and mRNA expression were evaluated in 64 PCNSL tissue samples. IFN-γ, IL-10, CD4, and CD8 mRNA expression was also evaluated.
RESULTS:PD-L1 protein was detected in tumor cells in 2 (4.1%) cases and in tumor microenvironments in 25 (52%) cases. PD-L1 mRNA positively correlated with IFN-γ (p=0.0024) and CD4 (p=0.0005) mRNA expression. IFN-γ mRNA positively correlated with CD8 mRNA expression (p=0.0001). Furthermore, tumor cell PD-L1 expression correlated positively with overall survival (p=0.0177), whereas microenvironmental PD-L1 expression exhibited an insignificant negative trend with overall survival (p=0.188).
CONCLUSION:PD-L1 was expressed on both tumor and/or tumor-infiltrating immune cells in PCNSL. The biological roles of this marker warrant further investigation.
Volume 37(10)
Pages 5655-5666
Published 2017-10-1
DOI 10.21873/anticanres.12001
PII 37/10/5655
PMID 28982883
MeSH Adult Aged Aged, 80 and over B7-H1 Antigen* / analysis B7-H1 Antigen* / genetics Biomarkers, Tumor* / analysis Biomarkers, Tumor* / genetics CD4 Antigens / genetics CD4-Positive T-Lymphocytes / chemistry CD4-Positive T-Lymphocytes / pathology CD8 Antigens / genetics CD8-Positive T-Lymphocytes / chemistry CD8-Positive T-Lymphocytes / pathology Central Nervous System Neoplasms / chemistry* Central Nervous System Neoplasms / genetics* Central Nervous System Neoplasms / mortality Central Nervous System Neoplasms / pathology Disease-Free Survival Female Humans Interferon-gamma / genetics Interleukin-10 / genetics Kaplan-Meier Estimate Lymphocytes, Tumor-Infiltrating / chemistry Lymphocytes, Tumor-Infiltrating / pathology Lymphoma / chemistry* Lymphoma / genetics* Lymphoma / mortality Lymphoma / pathology Male Middle Aged Proportional Hazards Models RNA, Messenger / genetics Retrospective Studies Tumor Microenvironment
Human and Animal Cells Raji