| RRC ID |
6555
|
| 著者 |
Hirano T, Morii H, Nakazawa K, Murakami D, Yamashita A, Asahi J, Orimo H, Tamae K, Tokura Y.
|
| タイトル |
Enhancement of adipogenesis induction by conditioned media obtained from cancer cells.
|
| ジャーナル |
Cancer Lett
|
| Abstract |
White adipose tissue is a multifunctional endocrine organ that synthesizes and secretes cytokine-like proteins termed adipokines. In the present study, the effects of cancer-derived medium on adipogenesis were examined. We prepared conditioned media from cancer cell lines, and cultured preadipocytes in the conditioned media. After 10 days of culture, intracellular lipid droplet accumulation was measured. We observed that the conditioned media significantly induced adipogenesis or enhanced the adipogenesis induced by adipogenesis inducers. Although we could not define the factors, these undefined factors derived from cancer cells may induce adipogenesis, and the resulting adipogenesis may affect cancer development.
|
| 巻・号 |
268(2)
|
| ページ |
286-94
|
| 公開日 |
2008-9-18
|
| DOI |
10.1016/j.canlet.2008.04.005
|
| PII |
S0304-3835(08)00276-0
|
| PMID |
18490102
|
| MeSH |
Adipogenesis*
Cell Communication
Cell Differentiation
Cell Line, Tumor
Culture Media, Conditioned
Humans
Neoplasms / etiology
Neoplasms / physiopathology*
Neovascularization, Pathologic / etiology
|
| IF |
7.36
|
| 引用数 |
9
|
|
WOS 分野
|
ONCOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
A431(RCB0202) |
