| RRC ID |
6557
|
| Author |
Kaneda M, Zhang D, Bhattacharjee R, Nakahama K, Arii S, Morita I.
|
| Title |
Vitamin K2 suppresses malignancy of HuH7 hepatoma cells via inhibition of connexin 43.
|
| Journal |
Cancer Lett
|
| Abstract |
The anti-cancer potential of vitamin K(2) (VK(2)) in hepatoma has gained considerable attention but the underlying mechanisms are unclear. Treatment of HuH7 hepatoma cells with VK(2) produced a normal liver phenotype. Following treatment of cells with VK(2), there was an increase in gap junctional intercellular communication activity, accompanied by up-regulation of connexin 32 (Cx32), dominantly expressed in normal hepatocyte. In contrast, Cx43 expression was inhibited. Moreover, the effect of VK(2) on Cx32 was abolished by over-expression of Cx43. Taken together, we propose that the anti-tumor effect of VK(2) is at least partly due to a decrease in Cx43 promoter activity.
|
| Volume |
263(1)
|
| Pages |
53-60
|
| Published |
2008-5-8
|
| DOI |
10.1016/j.canlet.2007.12.019
|
| PII |
S0304-3835(07)00628-3
|
| PMID |
18249064
|
| MeSH |
Base Sequence
Carcinoma, Hepatocellular / genetics
Carcinoma, Hepatocellular / pathology*
Cell Line, Tumor
Connexins / antagonists & inhibitors*
Connexins / genetics
DNA Primers
Humans
Immunohistochemistry
Liver Neoplasms / genetics
Liver Neoplasms / pathology*
Promoter Regions, Genetic
Vitamin K 2 / pharmacology*
|
| IF |
7.36
|
| Times Cited |
9
|
|
WOS Category
|
ONCOLOGY
|
| Resource |
| Human and Animal Cells |
|
