RRC ID 65696
Author Hayashi K, Tokuda A, Sakamoto W.
Title Hydroxyl Radical-Suppressing Mechanism and Efficiency of Melanin-Mimetic Nanoparticles.
Journal Int J Mol Sci
Abstract Harnessing melanins to scavenge free radicals in vivo may yield treatment methods for inflammatory disorders. Furthermore, elucidation of the mechanism underlying melanin-mediated suppression of free radicals, which is yet unclear, is warranted. Herein, we chemically synthesized melanin-mimetic nanoparticles (MeNPs) and investigated the mechanism underlying their use. MeNPs efficiently suppressed hydroxyl radicals by converting some MeNP hydroxyl groups to ketone groups. Furthermore, they suppressed hydroxyl radicals produced by lipopolysaccharide-treated Kupffer cells involved in hepatic cirrhosis pathogenesis, without causing significant cytotoxicity. The present results indicate the suitability of MeNPs to treat hepatic cirrhosis; however, further in vivo studies are warranted to determine their treatment efficacy.
Volume 19(8)
Published 2018-8-7
DOI 10.3390/ijms19082309
PII ijms19082309
PMID 30087240
PMC PMC6121240
MeSH Biomimetic Materials / chemistry Biomimetic Materials / pharmacology* Cell Line Free Radical Scavengers / chemistry Free Radical Scavengers / pharmacology* Humans Hydroxyl Radical / antagonists & inhibitors* Kupffer Cells / drug effects* Melanins / chemistry Melanins / pharmacology* Nanoparticles / chemistry*
IF 4.556
Human and Animal Cells KUP5(RCB4627)