論文 - 詳細
| RRC ID | 65696 |
|---|---|
| 著者 | Hayashi K, Tokuda A, Sakamoto W. |
| タイトル | Hydroxyl Radical-Suppressing Mechanism and Efficiency of Melanin-Mimetic Nanoparticles. |
| ジャーナル | Int J Mol Sci |
| Abstract |
Harnessing melanins to scavenge free radicals in vivo may yield treatment methods for inflammatory disorders. Furthermore, elucidation of the mechanism underlying melanin-mediated suppression of free radicals, which is yet unclear, is warranted. Herein, we chemically synthesized melanin-mimetic nanoparticles (MeNPs) and investigated the mechanism underlying their use. MeNPs efficiently suppressed hydroxyl radicals by converting some MeNP hydroxyl groups to ketone groups. Furthermore, they suppressed hydroxyl radicals produced by lipopolysaccharide-treated Kupffer cells involved in hepatic cirrhosis pathogenesis, without causing significant cytotoxicity. The present results indicate the suitability of MeNPs to treat hepatic cirrhosis; however, further in vivo studies are warranted to determine their treatment efficacy. |
| 巻・号 | 19(8) |
| 公開日 | 2018-8-7 |
| DOI | 10.3390/ijms19082309 |
| PII | ijms19082309 |
| PMID | 30087240 |
| PMC | PMC6121240 |
| MeSH | Biomimetic Materials / chemistry Biomimetic Materials / pharmacology* Cell Line Free Radical Scavengers / chemistry Free Radical Scavengers / pharmacology* Humans Hydroxyl Radical / antagonists & inhibitors* Kupffer Cells / drug effects* Melanins / chemistry Melanins / pharmacology* Nanoparticles / chemistry* |
| IF | 4.556 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | KUP5(RCB4627) |