| RRC ID |
65730
|
| 著者 |
Peng J, Fumoto S, Miyamoto H, Chen Y, Kuroda N, Nishida K.
|
| タイトル |
One-step formation of lipid-polyacrylic acid-calcium carbonate nanoparticles for co-delivery of doxorubicin and curcumin.
|
| ジャーナル |
J Drug Target
|
| Abstract |
A doxorubicin (Dox) and curcumin (Cur) combination treatment regimen has been widely studied in pre-clinical research. However, the nanoparticles developed for this combination therapy require a consecutive drug loading process because of the different water-solubility of these drugs. This study provides a strategy for the "one-step" formation of nanoparticles encapsulating both Dox and Cur. We took advantage of polyacrylic acid (PAA) and calcium carbonate (CaCO3) to realise a high drug entrapment efficiency (EE) and pH-sensitive drug release using a simplified preparation method. Optimisation of lipid ratios and concentrations of CaCO3 was conducted. Under optimal conditions, the mean diameter of PEGylated lipid/PAA/CaCO3 nanoparticles with encapsulated Cur and Dox (LPCCD) was less than 100 nm. An obvious pH-sensitive release of both drugs was observed, with different Dox and Cur release rates. Successful co-delivery of Cur and Dox was achieved via LPCCD on HepG2 cells. LPCCD altered the bio-distribution of Dox and Cur in vivo and decreased Dox-induced cardiotoxicity. The current investigation has developed an efficient ternary system for co-delivery of Dox and Cur to tumours, using a "one-step" formation resulting in nanoparticles possessing remarkable pH-sensitive drug release behaviour, which may be valuable for further clinical studies and eventual clinical application.
|
| 巻・号 |
25(8)
|
| ページ |
704-714
|
| 公開日 |
2017-9-1
|
| DOI |
10.1080/1061186X.2017.1315687
|
| PMID |
28368667
|
| MeSH |
Acrylic Resins / chemistry*
Animals
Calcium Carbonate / chemistry*
Curcumin / administration & dosage*
Doxorubicin / administration & dosage*
Hep G2 Cells
Humans
Lipids / chemistry*
Male
Mice
Nanoparticles / chemistry*
Rats
Rats, Wistar
|
| IF |
3.38
|
| リソース情報 |
| ヒト・動物細胞 |
Hep G2(RCB1886) |
