| RRC ID |
65774
|
| 著者 |
Wang H, Guo X, Wang X, Wang X, Chen J.
|
| タイトル |
Supracellular Actomyosin Mediates Cell-Cell Communication and Shapes Collective Migratory Morphology.
|
| ジャーナル |
iScience
|
| Abstract |
During collective cell migration, front cells tend to extend a predominant leading protrusion, which is rarely present in cells at the side or rear positions. Using Drosophila border cells (BCs) as a model system of collective migration, we revealed the presence of a supracellular actomyosin network at the peripheral surface of BC clusters. We demonstrated that the Myosin II-mediated mechanical tension as exerted by this peripheral supracellular network not only mediated cell-cell communication between leading BC and non-leading BCs but also restrained formation of prominent protrusions at non-leading BCs. Further analysis revealed that a cytoplasmic dendritic actin network that depends on the function of Arp2/3 complex interacted with the actomyosin network. Together, our data suggest that the outward pushing or protrusive force as generated from Arp2/3-dependent actin polymerization and the inward restraining force as produced from the supracellular actomyosin network together determine the collective and polarized morphology of migratory BCs.
|
| 巻・号 |
23(6)
|
| ページ |
101204
|
| 公開日 |
2020-6-26
|
| DOI |
10.1016/j.isci.2020.101204
|
| PII |
S2589-0042(20)30389-8
|
| PMID |
32535019
|
| PMC |
PMC7300135
|
| IF |
4.447
|
| リソース情報 |
| ショウジョウバエ |
7558R-1 |
