RRC ID 65840
Author Nagai K, Domon H, Oda M, Shirai T, Ohsumi T, Terao Y, Arai Y.
Title Antimicrobial activity of ethylene-vinyl acetate containing bioactive filler against oral bacteria.
Journal Dent Mater J
Abstract We developed an ethylene vinyl acetate (EVA) containing surface pre-reacted glass-ionomer (S-PRG) filler, as a new mouthguard material for preventing intraoral bacterial infection. We examined its physical properties, antimicrobial activity against a major cariogenic bacterium Streptococcus mutans and a periodontopathogen Porphyromonas gingivalis, and its cytotoxicity toward human gingival epithelial cells. S-PRG filler was added to EVA copolymer at 5, 10, 20, or 40 wt% and was processed into disc-shaped test specimens. Only minor differences between the Shore hardness and rebound resilience properties of EVA materials with and without the S-PRG filler were observed. The specimens with S-PRG filler showed bacteriostatic activity toward S. mutans and P. gingivalis and inhibited S. mutans biofilm formation. No cytotoxicity against the gingival epithelial cells was observed. Our findings show that EVA containing S-PRG filler has antimicrobial activity toward pathogenic oral bacteria and may be an effective material for maintaining the oral health of athletes.
Volume 36(6)
Pages 784-790
Published 2017-11-29
DOI 10.4012/dmj.2016-321
PMID 28747597
MeSH Anti-Infective Agents / pharmacology* Cell Line Epithelial Cells / drug effects* Ethylenes / pharmacology* Gingiva / cytology Glass Ionomer Cements / pharmacology* Hardness Humans Materials Testing Mouth Protectors* Porphyromonas gingivalis / drug effects* Streptococcus mutans / drug effects* Surface Properties Vinyl Compounds / pharmacology*
IF 1.359
Human and Animal Cells Ca9-22(RCB1976)