RRC ID 65881
Author Tanaka KI, Sugizaki T, Kanda Y, Tamura F, Niino T, Kawahara M.
Title Preventive Effects of Carnosine on Lipopolysaccharide-induced Lung Injury.
Journal Sci Rep
Abstract Acute respiratory distress syndrome (ARDS) is a potentially devastating form of acute lung injury, which involves neutrophilic inflammation and pulmonary cell death. Reactive oxygen species (ROS) play important roles in ARDS development. New compounds for inhibiting the onset and progression of ARDS are required. Carnosine (β-alanyl-L-histidine) is a small di-peptide with numerous activities, including antioxidant effects, metal chelation, proton buffering capacity and the inhibition of protein carbonylation and glycoxidation. We have examined the preventive effects of carnosine on tissue injury, oedema and inflammation in a murine model for ARDS. Oral administration of carnosine suppressed lipopolysaccharide (LPS)-induced vascular permeability, tissue injury and inflammation in the lung. In vivo imaging analysis revealed that LPS administration increased the level of ROS and that this increase was inhibited by carnosine administration. Carnosine also suppressed LPS-induced neutrophilic inflammation (evaluated by activation of myeloperoxidase in the lung and increased extracellular DNA in bronchoalveolar lavage fluid). Furthermore, carnosine administration suppressed the LPS-induced endoplasmic reticulum stress response in vivo. These results suggest that the oral administration of carnosine suppresses LPS-induced lung injury via carnosine's ROS-reducing activity. Therefore, carnosine may be beneficial for suppressing the onset and progression of ARDS.
Volume 7
Pages 42813
Published 2017-2-16
DOI 10.1038/srep42813
PII srep42813
PMID 28205623
PMC PMC5311717
MeSH Animals Carnosine / administration & dosage* Carnosine / pharmacology Disease Models, Animal Endoplasmic Reticulum Stress / drug effects Lipopolysaccharides / adverse effects* Male Mice Oxidative Stress / drug effects Reactive Oxygen Species / metabolism* Respiratory Distress Syndrome / chemically induced Respiratory Distress Syndrome / metabolism Respiratory Distress Syndrome / prevention & control*
IF 3.998
Human and Animal Cells RAW 264(RCB0535)