| RRC ID |
6588
|
| Author |
Okada N, Tanabe H, Tazoe H, Ishigami Y, Fukutomi R, Yasui K, Isemura M.
|
| Title |
Differentiation-associated alteration in sensitivity to apoptosis induced by (-)-epigallocatechin-3-O-gallate in HL-60 cells.
|
| Journal |
Biomed Res
|
| Abstract |
Green tea and its constituent (-)-epigallocatechin-3-O-gallate (EGCG) are known to have apoptosis-inducing activity on tumor cells including human leukemia HL-60 cells, providing an explanation for their anti-cancer effects. In the present study, we compared the sensitivity of undifferentiated cells and differentiated HL-60 cells with normal-like phenotypic characters. HL-60 cells treated with three differentiating agents were found to be resistant to EGCG-mediated apoptosis as compared with undifferentiated cells. Gene and protein expression of 67 kDa laminin receptor was down-regulated in differentiated HL-60 cells, suggesting its contribution to the difference in sensitivity in view of the fact that the receptor is a target of EGCG's action to induce apoptosis. The finding supports the view that EGCG induces apoptosis preferentially in cancer cells as compared with normal counterparts.
|
| Volume |
30(4)
|
| Pages |
201-6
|
| Published |
2009-8-1
|
| DOI |
10.2220/biomedres.30.201
|
| PII |
JST.JSTAGE/biomedres/30.201
|
| PMID |
19729850
|
| MeSH |
Antioxidants / pharmacology*
Apoptosis / drug effects*
Catechin / analogs & derivatives*
Catechin / pharmacology
Cell Differentiation / drug effects*
Gene Expression Regulation, Leukemic / drug effects
HL-60 Cells
Humans
Receptors, Laminin / biosynthesis
Tea*
|
| IF |
1.429
|
| Times Cited |
12
|
|
WOS Category
|
MEDICINE, RESEARCH & EXPERIMENTAL
|
| Resource |
| Human and Animal Cells |
HL60(RCB0041) |
