Reference - Detail
RRC ID | 65908 |
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Author | Fotso GW, Kamga J, Ngameni B, Uesugi S, Ohno M, Kimura KI, Momma H, Kwon E, Furuno H, Shiono Y, Ingrid SK, Yeboah SO, Ngadjui BT. |
Title | Secondary metabolites with antiproliferative effects from Albizia glaberrima var glabrescens Oliv. (Mimosoideae). |
Journal | Nat Prod Res |
Abstract |
A new 5-dehydroxyflavan, namely Albiziaflavan B or (+)-(2R, 3S, 4R)-3',4', 7-trihydroxy-4-methoxy-2,3-trans-flavan-3,4-trans-diol (1) was isolated from the root bark of Albizia glaberrima, together with six known compounds including three flavans: (+)-mollisacacidin (2), (+)-fustin (3) and butin (4); two steroids: chondrillasterol (5) and chondrillasterone (6), and a triterpenoid: lupeol (7). The structure of 1 was established by detailed analysis of its spectroscopic data, especially 1D and 2D NMR spectra, HRESIMS and CD data. Compounds 1-6 were assayed for their antiproliferative effects on two human cancer cells, HeLa at 50 μM (n = 2) and HL60 at 20 μM (n = 2). Compound 3 and 4 were the most active on HL60 with IC50 of 8.1 and 8.3 μM, respectively. Compound 6 was the most active with an IC50 of 4.6 μM on HeLa. |
Volume | 31(17) |
Pages | 1981-1987 |
Published | 2017-9-1 |
DOI | 10.1080/14786419.2016.1269097 |
PMID | 28103742 |
MeSH | Albizzia / chemistry Albizzia / metabolism* Antineoplastic Agents, Phytogenic / chemistry* Antineoplastic Agents, Phytogenic / pharmacology* Benzopyrans / chemistry Benzopyrans / isolation & purification Benzopyrans / pharmacology Cell Proliferation / drug effects Drug Screening Assays, Antitumor / methods Flavonoids / chemistry* Flavonoids / isolation & purification Flavonoids / pharmacology* HL-60 Cells HeLa Cells Humans Inhibitory Concentration 50 Magnetic Resonance Spectroscopy Molecular Structure Secondary Metabolism Steroids / chemistry* Steroids / pharmacology* |
IF | 2.158 |
Resource | |
Human and Animal Cells | HL60(RCB0041) |