論文 - 詳細
| RRC ID | 65921 |
|---|---|
| 著者 | Wathoni N, Motoyama K, Higashi T, Okajima M, Kaneko T, Arima H. |
| タイトル | Enhancement of curcumin wound healing ability by complexation with 2-hydroxypropyl-γ-cyclodextrin in sacran hydrogel film. |
| ジャーナル | Int J Biol Macromol |
| Abstract |
Curcumin is one of promising agents to accelerate the wound-healing process. However, the efficacy of curcumin is limited due to its poor water solubility and stability. To enhance the properties of curcumin, 2-hydroxypropyl-γ-cyclodextrin (HP-γ-CyD) can be used through complexation. Recently, we revealed that sacran has the potential to form a hydrogel film (HGF) as a wound dressing material. Therefore, in the present study, we investigated the wound healing ability of curcumin/HP-γ-CyD (Cur/HP-γ-CyD) complex in sacran-based HGF (Sac-HGF). We prepared the Cur/HP-γ-CyD complex in Sac-HGF without surface roughness. Additionally, the amorphous form in the Cur/HP-γ-CyD complex in Sac-HGF were observed. In contrast, the curcumin in Sac-HGF and curcumin/HP-γ-CyD physical mixture in Sac-HGF formed inhomogeneous films due to crystallization of curcumin. Furthermore, HP-γ-CyD played an important role to increase the elastic modulus of the Sac-HGF with high re-swelling ability. The Cur/HP-γ-CyD complex in Sac-HGF maintained antioxidant properties of curcumin. Curcumin was gradually released from the HP-γ-CyD complex in Sac-HGF. Notably, the Cur/HP-γ-CyD complex in Sac-HGF provided the highest wound healing ability in hairless mice. These results suggest that the Cur/HP-γ-CyD complex in Sac-HGF has the potential for use as a new transdermal therapeutic system to promote the wound-healing process. |
| 巻・号 | 98 |
| ページ | 268-276 |
| 公開日 | 2017-5-1 |
| DOI | 10.1016/j.ijbiomac.2017.01.144 |
| PII | S0141-8130(16)32521-1 |
| PMID | 28161536 |
| MeSH | Animals Antioxidants / chemistry Antioxidants / pharmacology Curcumin / chemistry* Curcumin / pharmacology* Drug Carriers / chemistry* Drug Liberation Drug Stability Methylgalactosides / chemistry* Mice NIH 3T3 Cells Polysaccharides / chemistry* Solubility Structure-Activity Relationship Water / chemistry Wound Healing / drug effects* gamma-Cyclodextrins / chemistry* gamma-Cyclodextrins / toxicity |
| IF | 5.162 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | NIH/3T3(RCB2767) |