Reference - Detail
| RRC ID | 65934 |
|---|---|
| Author | Fujihara K, Takahashi K, Koyama K, Kinoshita K. |
| Title | Triterpenoid saponins from Polaskia chichipe Backbg. and their inhibitory or promotional effects on the melanogenesis of B16 melanoma cells. |
| Journal | J Nat Med |
| Abstract |
Five new oleanane-type saponins 1-5 together with a known saponin 6 and a steroidal glycoside 7 were isolated from Polaskia chichipe Backbg., and their structures were determined from their 1D and 2D NMR and HRFABMS spectral data. The six isolated saponins 1-6 were tested for their effects on the melanogenesis of B16 melanoma 4A5 cells. Compound 1 exerted an inhibitory effect at 100 μM whereas compound 3 promoted melanogenesis at the same concentration, even though these two compounds contain the same aglycon structure. The dose-dependent activities of compounds 1 and 3 on melanin synthesis were investigated. |
| Volume | 71(4) |
| Pages | 606-616 |
| Published | 2017-10-1 |
| DOI | 10.1007/s11418-017-1082-9 |
| PII | 10.1007/s11418-017-1082-9 |
| PMID | 28497306 |
| MeSH | Animals Cactaceae / chemistry* Cell Line, Tumor Glycosides / chemistry Glycosides / isolation & purification Melanins / biosynthesis* Melanoma, Experimental / metabolism* Molecular Structure Oleanolic Acid / analogs & derivatives* Oleanolic Acid / chemistry Oleanolic Acid / isolation & purification Oleanolic Acid / pharmacology Plant Extracts / chemistry Plant Extracts / pharmacology* Saponins / chemistry Saponins / isolation & purification Saponins / pharmacology* Triterpenes / chemistry Triterpenes / isolation & purification Triterpenes / pharmacology* |
| IF | 2.055 |
| Resource | |
| Human and Animal Cells | B16 melanoma 4A5(RCB0557) |