| RRC ID |
6595
|
| Author |
Tianero MD, Hanif N, de Voogd NJ, van Soest RW, Tanaka J.
|
| Title |
A new antimicrobial fatty acid from the calcareous sponge Paragrantia cf. waguensis.
|
| Journal |
Chem Biodivers
|
| Abstract |
A new acetylenic fatty acid, 1, has been isolated from the title sponge. The structure of the molecule was elucidated to contain an enyne and a thiophene by spectroscopic methods. Compound 1 showed a weak cytotoxic effect against NBT-T2 rat bladder epithelial cells (IC(50) > 20 microg/ml), and antimicrobial activity with minimal-inhibitory concentrations (MIC) of 64 and 128 microg/ml against Staphylococcus aureus and Escherichia coli, respectively.
|
| Volume |
6(9)
|
| Pages |
1374-7
|
| Published |
2009-9-1
|
| DOI |
10.1002/cbdv.200800199
|
| PMID |
19774600
|
| MeSH |
Animals
Anti-Infective Agents / chemistry*
Anti-Infective Agents / isolation & purification
Anti-Infective Agents / toxicity
Cell Line
Fatty Acids, Unsaturated / chemistry*
Fatty Acids, Unsaturated / isolation & purification
Fatty Acids, Unsaturated / toxicity
Microbial Sensitivity Tests
Porifera / chemistry*
Rats
Thiophenes / chemistry*
Thiophenes / isolation & purification
Thiophenes / toxicity
|
| IF |
2.039
|
| Times Cited |
12
|
|
WOS Category
|
CHEMISTRY, MULTIDISCIPLINARY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Human and Animal Cells |
|
