Reference - Detail
| RRC ID | 6595 |
|---|---|
| Author | Tianero MD, Hanif N, de Voogd NJ, van Soest RW, Tanaka J. |
| Title | A new antimicrobial fatty acid from the calcareous sponge Paragrantia cf. waguensis. |
| Journal | Chem Biodivers |
| Abstract |
A new acetylenic fatty acid, 1, has been isolated from the title sponge. The structure of the molecule was elucidated to contain an enyne and a thiophene by spectroscopic methods. Compound 1 showed a weak cytotoxic effect against NBT-T2 rat bladder epithelial cells (IC(50) > 20 microg/ml), and antimicrobial activity with minimal-inhibitory concentrations (MIC) of 64 and 128 microg/ml against Staphylococcus aureus and Escherichia coli, respectively. |
| Volume | 6(9) |
| Pages | 1374-7 |
| Published | 2009-9-1 |
| DOI | 10.1002/cbdv.200800199 |
| PMID | 19774600 |
| MeSH | Animals Anti-Infective Agents / chemistry* Anti-Infective Agents / isolation & purification Anti-Infective Agents / toxicity Cell Line Fatty Acids, Unsaturated / chemistry* Fatty Acids, Unsaturated / isolation & purification Fatty Acids, Unsaturated / toxicity Microbial Sensitivity Tests Porifera / chemistry* Rats Thiophenes / chemistry* Thiophenes / isolation & purification Thiophenes / toxicity |
| IF | 2.039 |
| Times Cited | 12 |
| WOS Category | CHEMISTRY, MULTIDISCIPLINARY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | |