論文 - 詳細
| RRC ID | 65966 |
|---|---|
| 著者 | Matsumoto Y, Ishii M, Hasegawa S, Sekimizu K. |
| タイトル | Enterococcus faecalis YM0831 suppresses sucrose-induced hyperglycemia in a silkworm model and in humans. |
| ジャーナル | Commun Biol |
| Abstract |
Hyperglycemia caused by excessive intake of sucrose leads to lifestyle-related diseases such as diabetes. Administration of a lactic acid bacterial strain to mice suppresses sucrose-induced hyperglycemia, but evidence for a similar effect in humans is lacking. Here we show that Enterococcus faecalis YM0831, identified using an in vivo screening system with silkworms, suppressed sucrose-induced hyperglycemia in humans. E. faecalis YM0831 also suppressed glucose-induced hyperglycemia in silkworms. E. faecalis YM0831 inhibited glucose uptake by the human intestinal epithelial cell line Caco-2. A transposon insertion mutant of E. faecalis YM0831, which showed decreased inhibitory activity against glucose uptake by Caco-2 cells, also exhibited decreased inhibitory activity against both sucrose-induced and glucose-induced hyperglycemia in silkworms. In human clinical trials, oral ingestion of E. faecalis YM0831 suppressed the increase in blood glucose in a sucrose tolerance test. These findings suggest that E. faecalis YM0831 inhibits intestinal glucose transport and suppresses sucrose-induced hyperglycemia in humans. |
| 巻・号 | 2 |
| ページ | 157 |
| 公開日 | 2019-1-1 |
| DOI | 10.1038/s42003-019-0407-5 |
| PII | 407 |
| PMID | 31069266 |
| PMC | PMC6497652 |
| MeSH | Animals Biological Transport Bombyx / drug effects Bombyx / metabolism Bombyx / microbiology* Caco-2 Cells DNA Transposable Elements Disease Models, Animal Enterococcus faecalis / genetics Enterococcus faecalis / metabolism* Glucose / metabolism Glucose / pharmacology* Hemolymph / metabolism Hemolymph / microbiology Humans Hyperglycemia / chemically induced Hyperglycemia / microbiology Hyperglycemia / prevention & control* Intestinal Mucosa / metabolism Intestinal Mucosa / microbiology Mutagenesis, Insertional Sucrose / metabolism Sucrose / pharmacology* Symbiosis / physiology |
| IF | 4.165 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| カイコ | |