論文 - 詳細
| RRC ID | 66004 |
|---|---|
| 著者 | Niu X, Subramanian A, Hwang TH, Schilling TF, Galloway JL. |
| タイトル | Tendon Cell Regeneration Is Mediated by Attachment Site-Resident Progenitors and BMP Signaling. |
| ジャーナル | Curr Biol |
| Abstract |
The musculoskeletal system is a striking example of how cell identity and position is coordinated across multiple tissues to ensure function. However, it is unclear upon tissue loss, such as complete loss of cells of a central musculoskeletal connecting tendon, whether neighboring tissues harbor progenitors capable of mediating regeneration. Here, using a zebrafish model, we genetically ablate all embryonic tendon cells and find complete regeneration of tendon structure and pattern. We identify two regenerative progenitor populations, sox10+ perichondrial cells surrounding cartilage and nkx2.5+ cells surrounding muscle. Surprisingly, laser ablation of sox10+ cells, but not nkx2.5+ cells, increases tendon progenitor number in the perichondrium, suggesting a mechanism to regulate attachment location. We find BMP signaling is active in regenerating progenitor cells and is necessary and sufficient for generating new scxa+ cells. Our work shows that muscle and cartilage connective tissues harbor progenitor cells capable of fully regenerating tendons, and this process is regulated by BMP signaling. |
| 巻・号 | 30(17) |
| ページ | 3277-3292.e5 |
| 公開日 | 2020-9-7 |
| DOI | 10.1016/j.cub.2020.06.016 |
| PII | S0960-9822(20)30832-0 |
| PMID | 32649909 |
| PMC | PMC7484193 |
| MeSH | Animals Animals, Genetically Modified / genetics Animals, Genetically Modified / growth & development* Animals, Genetically Modified / metabolism Bone Morphogenetic Proteins / genetics Bone Morphogenetic Proteins / metabolism* Cell Differentiation Musculoskeletal System / metabolism* Regeneration* Stem Cells / cytology* Stem Cells / metabolism Tendons / cytology* Zebrafish / genetics Zebrafish / growth & development* Zebrafish / metabolism |
| IF | 9.601 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 22 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(6xTcf/LefBS-miniP:d2EGFP) isi01 Tg(UAS:nfsB-mCherry) rw0144 |