論文 - 詳細
| RRC ID | 66041 |
|---|---|
| 著者 | Kuji S, Watanabe R, Sato Y, Iwata T, Hirashima Y, Takekuma M, Ito I, Abe M, Nagashio R, Omae K, Aoki D, Kameya T. |
| タイトル | A new marker, insulinoma-associated protein 1 (INSM1), for high-grade neuroendocrine carcinoma of the uterine cervix: Analysis of 37 cases. |
| ジャーナル | Gynecol Oncol |
| Abstract |
OBJECTIVE:High-grade neuroendocrine carcinoma of uterine cervix (HGNCUC) has been recognized as a highly malignant tumor. Therapeutic strategy specific to neuroendocrine (NE) tumors needs to be considered, but some cases wouldn't allow simple final diagnoses. Insulinoma-associated protein 1 (INSM1), which is a zinc-finger transcription factor related to NE differentiation, is frequently expressed in NE tumors. We investigated the association between INSM1 and HGNCUC, and the possibility of INSM1 as a useful NE marker. METHODS:Thirty-seven cases of formalin-fixed and paraffin-embedded HGNCUCs were evaluated immunohistochemically for conventional NE markers and INSM1. We also surveyed polymerase chain reactions and examined the frequency and the genotype of human papillomavirus (HPV) infections. RESULTS:In HGNCUC, chromogranin A, synaptophysin and neural cell adhesion molecule (NCAM) were expressed in 86%, 86% and 68%, respectively. In addition, INSM1 was detected in 95%. Positivity for INSM1 was clearly evaluated histologically, because the intensity of nuclear staining on positive cells was high and nonspecific reactions were minimal. In uni- and multivariate analyses of prognostic factors on stage I and II surgical cases, the association between INSM1 expression and prognosis was insignificant. We confirmed 72% of 29 examined cases had high risk HPV infections (type 16, 14%; type 18, 86%). CONCLUSIONS:This study has clarified that INSM1 is closely related to the development of HGNCUC, and a useful new NE marker in conducting its correct and rapid diagnosis. |
| 巻・号 | 144(2) |
| ページ | 384-390 |
| 公開日 | 2017-2-1 |
| DOI | 10.1016/j.ygyno.2016.11.020 |
| PII | S0090-8258(16)31576-1 |
| PMID | 27908529 |
| MeSH | Biomarkers, Tumor / analysis* Carcinoma, Neuroendocrine / chemistry Carcinoma, Neuroendocrine / diagnosis* Cell Line, Tumor Female Humans Immunohistochemistry Papillomaviridae / genetics Repressor Proteins / analysis* Uterine Cervical Neoplasms / chemistry Uterine Cervical Neoplasms / diagnosis* |
| IF | 4.623 |
| リソース情報 | |
| ヒト・動物細胞 | RERF-LC-AI(RCB0444) |