| RRC ID |
66055
|
| Author |
Li W, Huang C, Liu Q, Koike K.
|
| Title |
Bistinospinosides A and B, Dimeric Clerodane Diterpene Glycosides from Tinospora sagittata.
|
| Journal |
J Nat Prod
|
| Abstract |
Two dimeric clerodane diterpene glycosides, namely, bistinospinosides A (1) and B (2), were isolated from the roots of Tinospora sagittata. Their structures were elucidated by extensive spectroscopic data interpretation. The compounds feature an unusual 1,4-epoxycyclohexane ring in their structures and may be biosynthetically constructed via an intermolecular Diels-Alder [4+2] cycloaddition from the corresponding clerodane diterpene. The compounds were evaluated in a nitric oxide inhibitory assay using J774.1 macrophage-like cells.
|
| Volume |
80(9)
|
| Pages |
2478-2483
|
| Published |
2017-9-22
|
| DOI |
10.1021/acs.jnatprod.7b00324
|
| PMID |
28836430
|
| MeSH |
Diterpenes, Clerodane / chemistry
Diterpenes, Clerodane / isolation & purification*
Diterpenes, Clerodane / pharmacology*
Glycosides / chemistry
Glycosides / isolation & purification*
Glycosides / pharmacology*
Macrophages / chemistry
Macrophages / drug effects*
Molecular Structure
Nitric Oxide / analysis*
Nitric Oxide / chemistry
Plant Roots / chemistry*
Tinospora / chemistry*
|
| IF |
3.782
|
| Resource |
| Human and Animal Cells |
J774.1 |
