| RRC ID |
66153
|
| 著者 |
Fukami K, Asano E, Ueda M, Sekiguchi F, Yoshida S, Kawabata A.
|
| タイトル |
High glucose induces N-linked glycosylation-mediated functional upregulation and overexpression of Cav3.2 T-type calcium channels in neuroendocrine-like differentiated human prostate cancer cells.
|
| ジャーナル |
J Pharmacol Sci
|
| Abstract |
Given that Cav3.2 T-type Ca2+ channels were functionally regulated by asparagine (N)-linked glycosylation, we examined effects of high glucose on the function of Cav3.2, known to regulate secretory function, in neuroendocrine-like differentiated prostate cancer LNCaP cells. High glucose accelerated the increased channel function and overexpression of Cav3.2 during neuroendocrine differentiation, the former prevented by enzymatic inhibition of N-glycosylation and cleavage of N-glycans. Hyperglycemia thus appears to induce N-linked glycosylation-mediated functional upregulation and overexpression of Cav3.2 in neuroendocrine-like differentiated prostate cancer cells.
|
| 巻・号 |
133(1)
|
| ページ |
57-60
|
| 公開日 |
2017-1-1
|
| DOI |
10.1016/j.jphs.2016.12.004
|
| PII |
S1347-8613(16)30173-6
|
| PMID |
28081948
|
| MeSH |
1-Methyl-3-isobutylxanthine / pharmacology
Bucladesine / pharmacology
Calcium Channels, T-Type / biosynthesis*
Cell Differentiation*
Cell Line, Tumor
Gene Expression Regulation, Neoplastic*
Glucose / pharmacology*
Glycosylation / drug effects
Humans
Male
Membrane Potentials / drug effects
Prostatic Neoplasms / metabolism*
Prostatic Neoplasms / pathology*
Tunicamycin / pharmacology
Up-Regulation / drug effects*
|
| IF |
2.835
|
| リソース情報 |
| ヒト・動物細胞 |
LNCap.FGC(RCB2144) |
