Reference - Detail
| RRC ID | 66252 |
|---|---|
| Author | Le VVH, Davies IG, Moon CD, Wheeler D, Biggs PJ, Rakonjac J. |
| Title | Novel 5-Nitrofuran-Activating Reductase in Escherichia coli. |
| Journal | Antimicrob Agents Chemother |
| Abstract |
The global spread of multidrug-resistant enterobacteria warrants new strategies to combat these pathogens. One possible approach is the reconsideration of “old” antimicrobials, which remain effective after decades of use. Synthetic 5-nitrofurans such as furazolidone, nitrofurantoin, and nitrofurazone are such a class of antimicrobial drugs. |
| Volume | 63(11) |
| Published | 2019-11-1 |
| DOI | 10.1128/AAC.00868-19 |
| PII | AAC.00868-19 |
| PMID | 31481448 |
| PMC | PMC6811407 |
| MeSH | Anti-Bacterial Agents / metabolism Anti-Bacterial Agents / pharmacology Drug Resistance, Bacterial / genetics Escherichia coli / drug effects Escherichia coli / enzymology* Escherichia coli / genetics Escherichia coli Proteins / genetics Escherichia coli Proteins / metabolism Furazolidone / chemistry Furazolidone / pharmacology Microbial Sensitivity Tests Molecular Docking Simulation Nitrofurans / metabolism Nitrofurans / pharmacology Nitrofurantoin / chemistry Nitrofurantoin / pharmacology Nitrofurazone / chemistry Nitrofurazone / pharmacology Nitroreductases / genetics Nitroreductases / metabolism* Peroxiredoxins / genetics Peroxiredoxins / metabolism |
| IF | 4.904 |
| Resource | |
| Prokaryotes E. coli | ASKA collection JW0599 |