論文 - 詳細
| RRC ID | 66407 |
|---|---|
| 著者 | Liu H, Hu Y, Zhu Y, Wu X, Zhou X, Pan H, Chen S, Tian P. |
| タイトル | A simultaneous grafting/vinyl polymerization process generates a polycationic surface for enhanced antibacterial activity of bacterial cellulose. |
| ジャーナル | Int J Biol Macromol |
| Abstract |
Bacterial cellulose (BC) is a biosynthesized carbohydrate polymer with excellent biocompatibility and water holding capability. However, it lacks an inherent antibacterial activity that has limited its in-depth biomedical applications. This study investigated a novel strategy of adopting a simultaneous process to chemically anchor a quaternary ammonium salt (R-N(CH3)+) with a special vinyl group (2-methacryloyloxyethyl trimethylammonium chloride, METAC) onto the BC, and meanwhile, enhance the density of (R-N(CH3)+) via free radical vinyl polymerization. The results have confirmed the transition of BC surface from a negatively-charged surface to a polycationic surface via such a simultaneous reaction. As compared to chitin film (a representative of R-NH3+), the resulting METAC-grafted BC (a representative of high-density R- N(CH3)+) acquired excellent water absorbability (40 times of dry weight of the BC), 99% antibacterial activity against Escherichia coli and Staphylococcus aureus, a satisfactory in-vitro biocompatibility, and a better in-vivo wound healing outcome with an excellent in-vivo antibacterial efficacy. This study has exhibited potential in utilizing a facile method to prepare a bio-safe, adaptive antibacterial surface for various biomedical applications. |
| 巻・号 | 143 |
| ページ | 224-234 |
| 公開日 | 2020-1-15 |
| DOI | 10.1016/j.ijbiomac.2019.12.052 |
| PII | S0141-8130(19)35562-X |
| PMID | 31816376 |
| MeSH | Anti-Bacterial Agents / chemical synthesis Anti-Bacterial Agents / chemistry Anti-Bacterial Agents / pharmacology* Carbohydrates / chemical synthesis Carbohydrates / chemistry Carbohydrates / pharmacology* Cellulose / chemical synthesis Cellulose / chemistry Cellulose / pharmacology* Chitin / chemistry Escherichia coli / drug effects Escherichia coli / pathogenicity Methacrylates / chemistry Methacrylates / pharmacology Polymers / chemical synthesis Polymers / chemistry Polymers / pharmacology* Quaternary Ammonium Compounds / chemical synthesis Quaternary Ammonium Compounds / chemistry Quaternary Ammonium Compounds / pharmacology Staphylococcus aureus / drug effects Staphylococcus aureus / pathogenicity Surface Properties / drug effects Wound Healing |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM9730 |