論文 - 詳細
| RRC ID | 66408 |
|---|---|
| 著者 | Lee JM, Jang WJ, Park SH, Kong IS. |
| タイトル | Antioxidant and gastrointestinal cytoprotective effect of edible polypeptide poly-γ-glutamic acid. |
| ジャーナル | Int J Biol Macromol |
| Abstract |
The antioxidant effects and cytoprotection of the poly-γ-glutamic acid (γ-PGA) were investigated. γ-PGA with a molecular weight of ~400 kDa showed hydroxyl radical (OH•) averting capacity (HORAC), 85.2% at 1 mg/mL, which was caused by the chelation of transition metal ions and scavenging hydrogen peroxide. Moreover, this γ-PGA showed 94.1% superoxide anion radical (O2•-) scavenging and 96.0% lipid peroxidation inhibition activity at the same concentrations. The IC50 values were 130 ± 4.2, 107 ± 3.5 and 128 ± 3.8 μg/mL against OH•, O2•- and lipid peroxidation, respectively. There was no significant variation in the HORAC of γ-PGA after 9 h, the end point of the simulated digestion model. Furthermore, γ-PGA showed a completely protective effect in Caco-2 cells and probiotic bacteria against oxidative damage at 1 mg/mL. These data suggest that γ-PGA has a potential use as a cytoprotectant in food and feed supplements, cosmetics and biomedical fields. |
| 巻・号 | 153 |
| ページ | 616-624 |
| 公開日 | 2020-6-15 |
| DOI | 10.1016/j.ijbiomac.2020.03.050 |
| PII | S0141-8130(20)30370-6 |
| PMID | 32165198 |
| MeSH | Antioxidants* / chemistry Antioxidants* / pharmacology Caco-2 Cells Cytoprotection / drug effects* Humans Lipid Peroxidation / drug effects* Oxidative Stress / drug effects* Polyglutamic Acid / analogs & derivatives* Polyglutamic Acid / chemistry Polyglutamic Acid / pharmacology |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM15709 |