論文 - 詳細
| RRC ID | 66749 |
|---|---|
| 著者 | Huo Y, Lu X, Wang X, Wang X, Chen L, Guo H, Zhang M, Li Y. |
| タイトル | Bifidobacterium animalis subsp. lactis A6 Alleviates Obesity Associated with Promoting Mitochondrial Biogenesis and Function of Adipose Tissue in Mice. |
| ジャーナル | Molecules |
| Abstract |
Probiotics are widely known for their health benefits. Mitochondrial dysfunction is related to obesity. The aim of this study was to illuminate whether Bifidobacterium animalis subsp. lactis A6 (BAA6) could improve obesity due to increased mitochondrial biogenesis and function of adipose tissues. Four-week-old male C57BL/6 mice were fed with a high-fat diet (HFD) for 17 weeks. For the final eight weeks, the HFD group was divided into three groups including HFD, HFD with BAA6 (HFD + BAA6 group), and HFD with Akkermansia muciniphila (AKK) (HFD + AKK group as positive control). The composition of the microbiota, serum lipopolysaccharides (LPS), and mitochondrial biosynthesis and function of epididymal adipose tissues were measured. Compared with the HFD group, body weight, relative fat weight, the relative abundance of Oscillibacter and Bilophila, and serum LPS were significantly decreased in the HFD + BAA6 and HFD + AKK groups (p < 0.05). Furthermore, the addition of BAA6 and AKK increased the expression of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) (by 21.53- and 18.51-fold), estrogen-related receptor α (ERRα) (by 2.83- and 1.24-fold), and uncoupling protein-1 (UCP-1) (by 1.51- and 0.60-fold) in epididymal adipose tissues. Our results suggest that BAA6 could improve obesity associated with promoting mitochondrial biogenesis and function of adipose tissues in mice. |
| 巻・号 | 25(7) |
| 公開日 | 2020-3-25 |
| DOI | 10.3390/molecules25071490 |
| PII | molecules25071490 |
| PMID | 32218367 |
| PMC | PMC7180933 |
| MeSH | Adipose Tissue / metabolism* Administration, Oral Akkermansia Animals Bifidobacterium animalis / physiology* Body Weight Cytokines / metabolism Diet, High-Fat Gastrointestinal Microbiome Inflammation / blood Inflammation / pathology Inflammation Mediators / metabolism Lipid Metabolism Lipids / blood Lipopolysaccharides / blood Male Mice, Inbred C57BL Mice, Obese Mitochondria / metabolism Nitric Oxide Synthase Type III / metabolism Obesity / blood Obesity / microbiology* Organelle Biogenesis* Weight Loss |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| 一般微生物 | JCM30893 |