論文 - 詳細
| RRC ID | 66756 |
|---|---|
| 著者 | Nagao-Kitamoto H, Leslie JL, Kitamoto S, Jin C, Thomsson KA, Gillilland MG 3rd, Kuffa P, Goto Y, Jenq RR, Ishii C, Hirayama A, Seekatz AM, Martens EC, Eaton KA, Kao JY, Fukuda S, Higgins PDR, Karlsson NG, Young VB, Kamada N. |
| タイトル | Interleukin-22-mediated host glycosylation prevents Clostridioides difficile infection by modulating the metabolic activity of the gut microbiota. |
| ジャーナル | Nat Med |
| Abstract |
The involvement of host immunity in the gut microbiota-mediated colonization resistance to Clostridioides difficile infection (CDI) is incompletely understood. Here, we show that interleukin (IL)-22, induced by colonization of the gut microbiota, is crucial for the prevention of CDI in human microbiota-associated (HMA) mice. IL-22 signaling in HMA mice regulated host glycosylation, which enabled the growth of succinate-consuming bacteria Phascolarctobacterium spp. within the gut microbiome. Phascolarctobacterium reduced the availability of luminal succinate, a crucial metabolite for the growth of C. difficile, and therefore prevented the growth of C. difficile. IL-22-mediated host N-glycosylation is likely impaired in patients with ulcerative colitis (UC) and renders UC-HMA mice more susceptible to CDI. Transplantation of healthy human-derived microbiota or Phascolarctobacterium reduced luminal succinate levels and restored colonization resistance in UC-HMA mice. IL-22-mediated host glycosylation thus fosters the growth of commensal bacteria that compete with C. difficile for the nutritional niche. |
| 巻・号 | 26(4) |
| ページ | 608-617 |
| 公開日 | 2020-4-1 |
| DOI | 10.1038/s41591-020-0764-0 |
| PII | 10.1038/s41591-020-0764-0 |
| PMID | 32066975 |
| PMC | PMC7160049 |
| MeSH | Animals Bacteria / drug effects Bacteria / growth & development* Bacteria / metabolism* Clostridioides difficile / drug effects Clostridioides difficile / immunology* Clostridium Infections / immunology Clostridium Infections / prevention & control* Enterocolitis, Pseudomembranous / immunology Enterocolitis, Pseudomembranous / metabolism Enterocolitis, Pseudomembranous / microbiology Enterocolitis, Pseudomembranous / prevention & control Female Gastrointestinal Microbiome / drug effects Gastrointestinal Microbiome / physiology* Glycosylation / drug effects Host Microbial Interactions / drug effects Host Microbial Interactions / genetics Host Microbial Interactions / immunology Humans Interleukin-22 Interleukins / pharmacology Interleukins / physiology* Male Mice Mice, Inbred C57BL Mice, Knockout Veillonellaceae / drug effects Veillonellaceae / growth & development Veillonellaceae / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 64 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM30894 JCM16074 |